SCHEMBL81205

SCHEMBL81205

FC(F)(F)c1cc(I)cc(C(F)(F)F)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.46
IDO1 P14902 2/20 0.41
ADRB1 P08588 1/20 0.37
TSHR P16473 4/20 0.36
ALDH1A1 P00352 2/20 0.36
RXRA P19793 2/20 0.35
RXRB P28702 2/20 0.35
RXRG P48443 2/20 0.35
MAPT P10636 1/20 0.35
RAPGEF4 Q8WZA2 1/20 0.35
ITGB3 P05106 1/20 0.35
ITGAV P06756 1/20 0.35
CYP3A4 P08684 1/20 0.33
HPGD P15428 1/20 0.33
ALOX15 P16050 1/20 0.33
HIF1A Q16665 1/20 0.33
TXNRD1 Q16881 1/20 0.33
TXNRD3 Q86VQ6 1/20 0.33
TXNRD2 Q9NNW7 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2159227 0.94 CES2 (0.40) CES2IDO1ADRB1TSHRALDH1A1
SCHEMBL18077879 0.87 GABRB2 (0.42) CES2IDO1ADRB1MAPTRAPGEF4
SCHEMBL30074464 0.84 RXRA (0.36) CES2IDO1TSHRALDH1A1RXRA
SCHEMBL18260731 0.84 RXRA (0.36) CES2IDO1TSHRALDH1A1RXRA
SCHEMBL440959 0.83 CES2 (0.58) CES2IDO1ADRB1TSHRALDH1A1
SCHEMBL23133410 0.82 CES2 (0.33) CES2IDO1
SCHEMBL9598566 0.82 PTGS1 (0.39) CES2IDO1TRPV1
SCHEMBL14303165 0.82 CES2 (0.33) CES2IDO1
SCHEMBL13404348 0.82 RAPGEF4 (0.42) CES2MAPTRAPGEF4XPO1
SCHEMBL979567 0.82 RAPGEF4 (0.41) CES2TSHRALDH1A1RAPGEF4CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 293 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-121574107-A Method for synthesizing aryl thiobenzothiazole compound based on cuprous chloride 苏州大学 2026-02-27 CN claimed
US-20250326731-A1 CATALYST-CONTROLLED SITE-SELECTIVE METHYLENE C-H LACTONIZATION OF DICARBOXYLIC ACIDS SCRIPPS RESEARCH INST (US) 2025-10-23 US claimed
EP-4522595-A2 CATALYST-CONTROLLED SITE-SELECTIVE METHYLENE C-H LACTONIZATION OF DICARBOXYLIC ACIDS The Scripps Research Institute (US) 2025-03-19 EP claimed
CN-118759626-B Optical filter plated with ultralow antireflection film and process thereof 星浪光学科技(江苏)有限公司 2025-03-11 CN claimed
CN-118931159-A Preparation process of high-toughness wear-resistant TPU composite material 江苏增强新材料科技有限公司 2024-11-12 CN claimed
CN-118759626-A Optical filter plated with ultralow antireflection film and process thereof 星浪光学科技(江苏)有限公司 2024-10-11 CN claimed
CN-117886706-A Monoamine monomer containing trifluoromethyl and alkynyl, application of monoamine monomer, photosensitive polyimide film and preparation method of photosensitive polyimide film 安徽国风新材料股份有限公司 2024-04-16 CN claimed
CN-115215798-B Aromatic cyanation synthesis method of inert olefin 恒升德康(南京)医药科技有限公司 2024-02-06 CN claimed
WO-2023220559-A2 CATALYST-CONTROLLED SITE-SELECTIVE METHYLENE C-H LACTONIZATION OF DICARBOXYLIC ACIDS THE SCRIPPS RESEARCH INSTITUTE (US) 2023-11-16 WO claimed
CN-115215798-A Aromatic cyaniding synthesis method of inert olefin 恒升德康(南京)医药科技有限公司 2022-10-21 CN claimed
CN-114957092-A Organic luminescent material, preparation method and application 南京邮电大学 2022-08-30 CN claimed
CN-113214045-A Preparation process of high-purity 3, 5-bis (trifluoromethyl) benzyl alcohol 宁夏忠同生物科技有限公司 2021-08-06 CN claimed
CN-102286142-B Dibenzofuran and derivatives, preparation method and application thereof NINGBO INST MAT TECH & ENG CAS 2014-09-03 CN claimed
CN-103880877-A Fluorine-containing solid-phase synthesis reagent and application thereof SHANGHAI INST ORGANIC CHEM 2014-06-25 CN claimed
US-6878663-B2 Method for producing palladium complex compound CENTRAL GLASS COMPANY, LIMITED (JP) 2005-04-12 US claimed
EP-1008601-B1 Method for producing palladium complex compound CENTRAL GLASS CO LTD (JP) 2005-03-09 EP claimed
US-20020111482-A1 Method for producing palladium complex compound CENTRAL GLASS COMPANY, LIMITED 2002-08-15 US claimed
US-6326517-B1 REACTIN AN AROMATIC COMPOUND WITH CARBON MONOXIDE AND AMMONIA CENTRAL GLASS COMPANY, LIMITED (JP) 2001-12-04 US claimed
US-6268527-B1 REACTING TRIFLUOROMETHYL SUBSTITUTED AROMATIC COMPOUND WITH CARBON MONOXIDE AND HYDROXY COMPOUND IN PRESENCE OF METAL COMPOUND AND PHOSPHINE DERIVATIVE TO PRODUCE TRIFLUOROMETHYL SUBSTITUTED BENZOIC ACID DERIVATIVE CENTRAL GLASS COMPANY, LIMITED (JP) 2001-07-31 US claimed
EP-1008601-A2 Method for producing palladium complex compound Central Glass Company, Limited (JP) 2000-06-14 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250326731-A1 CATALYST-CONTROLLED SITE-SELECTIVE METHYLENE C-H LACTONIZATION OF DICARBOXYLIC ACIDS DNPH1, NISCH, PTMA CES2 1303/4885IDO1 1661/4885ADRB1 4449/4885
US-20020111482-A1 Method for producing palladium complex compound PDCD1LG2, CD274, PDCD1 CES2 3861/4885IDO1 69/4885ADRB1 693/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.