SCHEMBL812433

SCHEMBL812433

NC(=O)c1c(Cl)c(Cl)c(C(N)=O)c(Cl)c1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 0.41
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
LMNA P02545 2/20 0.36
F2 P00734 1/20 0.36
TDP1 Q9NUW8 2/20 0.33
PARP1 P09874 2/20 0.33
ALDH1A1 P00352 1/20 0.33
OR51E2 Q9H255 1/20 0.33
SIRT6 Q8N6T7 1/20 0.33
TSHR P16473 3/20 0.31
ACHE P22303 1/20 0.31
KMT2A Q03164 1/20 0.31
ATM Q13315 1/20 0.31
PRNP P04156 1/20 0.31
MAPK1 P28482 1/20 0.31
PPARG P37231 1/20 0.31
HTT P42858 1/20 0.31
MAPK10 P53779 1/20 0.31
NCOA2 Q15596 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10804236 0.97 CES2 (0.42) POLBCES2CES1LMNAF2
SCHEMBL28938074 0.94 CES2 (0.40) POLBCES2CES1LMNAF2
SCHEMBL1456243 0.90 CES2 (0.42) POLBCES2CES1LMNAF2
SCHEMBL6206671 0.80 MEN1 (0.50) POLBALDH1A1KMT2AMAPK1CYP3A4
SCHEMBL16122071 0.80 CES2 (0.52) POLBCES2CES1LMNAF2
SCHEMBL11749620 0.80 LMNA (0.45) POLBCES2CES1LMNAF2
SCHEMBL8918066 0.80 HTT (0.42) POLBCES2CES1LMNAF2
SCHEMBL28841304 0.78 POLB (0.42) POLBCES2CES1ALDH1A1TSHR
SCHEMBL6206148 0.76 MEN1 (0.52) CES2CES1ALDH1A1KMT2AMAPK1
SCHEMBL2194475 0.76 POLB (0.50) POLBLMNATDP1PARP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6452046-B2 HEATING 2,3,5,6-TETRACHLORO-1,4-BENZENEDIAMIDE SDS BIOTECH K.K. (JP) 2002-09-17 US claimed
US-20010025121-A1 Process for producing 2, 3, 5, 6-tetrachloro-1, 4-benzenedicarboxylic acid SDS BIOTECH K.K. 2001-09-27 US claimed
CN-114728879-B Method for producing 2,3,5, 6-tetrachloro-1, 4-dimethyl phthalate SDS生物技术株式会社 2023-11-14 CN disclosed
US-11512037-B2 Process for producing dimethyl 2,3,5,6-tetrachloro-1,4-benzenedicarboxylate SDS BIOTECH K.K. (JP) 2022-11-29 US disclosed
US-20220267244-A1 PROCESS FOR PRODUCING DIMETHYL 2,3,5,6-TETRACHLORO-1,4-BENZENEDICARBOXYLATE SDS BIOTECH K.K. (JP) 2022-08-25 US disclosed
CN-114728879-A Method for producing dimethyl 2,3,5, 6-tetrachloro-1, 4-phthalate SDS生物技术株式会社 2022-07-08 CN disclosed
EP-2404897-A1 METHOD FOR PRODUCING HALOGEN-SUBSTITUTED BENZENE DIMETHANOL Sumitomo Chemical Company, Limited (JP) 2012-01-11 EP disclosed
US-20110313197-A1 METHOD FOR PRODUCING HALOGEN-SUBSTITUTED BENZENE DIMETHANOL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-12-22 US disclosed
CN-1810773-A Method for industrially preparing tetrachloroterephthalonitrile WEI XIAOTING (CN) 2006-08-02 CN disclosed
US-6452046-B2 HEATING 2,3,5,6-TETRACHLORO-1,4-BENZENEDIAMIDE SDS BIOTECH K.K. (JP) 2002-09-17 US disclosed
US-6452046-B2 HEATING 2,3,5,6-TETRACHLORO-1,4-BENZENEDIAMIDE SDS BIOTECH K.K. (JP) 2002-09-17 US disclosed
US-20010025121-A1 Process for producing 2, 3, 5, 6-tetrachloro-1, 4-benzenedicarboxylic acid SDS BIOTECH K.K. 2001-09-27 US disclosed
US-20010025121-A1 Process for producing 2, 3, 5, 6-tetrachloro-1, 4-benzenedicarboxylic acid SDS BIOTECH K.K. 2001-09-27 US disclosed
US-4053510-A REACTING A DICARBOXYLIC ACID WITH UREA IN CHLOROSULFONIC ACID OR OLEUM AKZO N.V. (NL) 1977-10-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220267244-A1 PROCESS FOR PRODUCING DIMETHYL 2,3,5,6-TETRACHLORO-1,4-BENZENEDICARBOXYLATE PKD1, PKD2, BCKDK POLB 2284/4885CES2 2792/4885CES1 1973/4885
US-20010025121-A1 Process for producing 2, 3, 5, 6-tetrachloro-1, 4-benzenedicarboxylic acid HAO2, HAAO, HAO1 POLB 2283/4885CES2 679/4885CES1 568/4885
US-20110313197-A1 METHOD FOR PRODUCING HALOGEN-SUBSTITUTED BENZENE DIMETHANOL DBH, DDT, CBR3 POLB 1977/4885CES2 312/4885CES1 2025/4885
US-11512037-B2 Process for producing dimethyl 2,3,5,6-tetrachloro-1,4-benzenedicarboxylate PKD1, PKD2, BCKDK POLB 2284/4885CES2 2792/4885CES1 1973/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.