Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.34 |
| ▸ | SDHB | P21912 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6377001 | 0.85 | HSD11B1 (0.42) | ARHSD11B1TRPA1TRPM8TRPV1 | |
| SCHEMBL14483362 | 0.83 | GLA (0.38) | — | |
| SCHEMBL2437987 | 0.81 | PDE3B (0.36) | ARHSD11B1TRPA1GPBAR1 | |
| SCHEMBL28313455 | 0.79 | ALDH1A1 (0.45) | ARHSD11B1 | |
| SCHEMBL5541462 | 0.79 | HSD11B1 (0.55) | ARHSD11B1S1PR1TRPA1TRPM8 | |
| SCHEMBL1371322 | 0.79 | TSHR (0.39) | HTT | |
| SCHEMBL145873 | 0.77 | AR (0.32) | ARHSD11B1 | |
| SCHEMBL1372192 | 0.77 | TSHR (0.41) | — | |
| SCHEMBL7370399 | 0.77 | KDM4E (0.37) | HSD11B1TRPA1 | |
| SCHEMBL8129047 | 0.77 | ACHE (0.41) | AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103097365-A | 5- (biphenyl-4-yl) -3-phenyl-1, 2, 4-oxadiazolyl derivatives as ligands on sphingosine-1-phosphate (S1P) receptors | MERCK SERONO SA | 2013-05-08 | — | — | CN | disclosed |
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |