Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6377001 | 0.87 | HSD11B1 (0.42) | HSD11B1TRPA1ARNOTUM | |
| SCHEMBL2049472 | 0.86 | HSD11B1 (0.42) | PDE3BPDE3AGPR3KCNN4HSD11B1 | |
| SCHEMBL14483362 | 0.84 | GLA (0.38) | — | |
| SCHEMBL2049475 | 0.82 | PDK2 (0.33) | HSD11B1TRPA1PDK2 | |
| SCHEMBL8124404 | 0.81 | AR (0.44) | HSD11B1TRPA1ARGPBAR1 | |
| SCHEMBL28313455 | 0.81 | ALDH1A1 (0.45) | HSD11B1ARPDK2NOTUM | |
| SCHEMBL434024 | 0.81 | KDM4E (0.34) | NOTUM | |
| SCHEMBL1274101 | 0.80 | KIF11 (0.40) | PDE3BPDE3AAKR1C3AKR1C2PDK2 | |
| SCHEMBL2052768 | 0.79 | PDE3B (0.39) | PDE3BPDE3ATRPA1ARGPBAR1 | |
| SCHEMBL2053792 | 0.79 | PDE3B (0.38) | PDE3BPDE3AAKR1C3AKR1C2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0059291-B1 | ANTIHYPERTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-03-27 | — | — | EP | claimed |
| WO-2013182433-A1 | A PROCESS USING GRIGNARD REAGENTS | BASF SE (DE) | 2013-12-12 | — | — | WO | disclosed |
| EP-2547687-A1 | A PROCESS USING GRIGNARD REAGENTS | BASF SE (DE) | 2013-01-23 | — | — | EP | disclosed |
| EP-2513067-A1 | METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF | BASF SE (DE) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011113820-A1 | A PROCESS USING GRIGNARD REAGENTS | BASF SE (DE) | 2011-09-22 | — | — | WO | disclosed |
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |