Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 6/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6074317 | 1.00 | ADRB2 (0.40) | ADRB2ADRB1ADRB3 | |
| SCHEMBL8879834 | 0.83 | ADRB2 (0.44) | ADRB2ADRB1ADRB3 | |
| SCHEMBL6074550 | 0.83 | ADRB2 (0.39) | ADRB2ADRB1ADRB3 | |
| SCHEMBL10341872 | 0.80 | ADRB2 (0.45) | ADRB2ADRB1ADRB3 | |
| SCHEMBL8684187 | 0.77 | ALDH1A1 (0.40) | — | |
| SCHEMBL8135825 | 0.76 | MME (0.33) | ADRB2ADRB1ADRB3 | |
| SCHEMBL4538650 | 0.76 | ADRB2 (0.54) | ADRB2ADRB1ADRB3 | |
| Broxaterol SCHEMBL82745 | 0.75 | ADRB2 (0.46) | ADRB2ADRB1ADRB3 | |
| SCHEMBL8557552 | 0.72 | ADRB2 (0.32) | ADRB2ADRB1ADRB3 | |
| SCHEMBL8557911 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4520200-A | CHEMICAL INTERMEDIATES FOR BRONCHODILATOR AGENT | ZAMBON S.P.A. (IT) | 1985-05-28 | — | — | US | claimed |
| EP-0016255-B1 | ISOXAZOLE DERIVATIVE, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | ZAMBON S.p.A. (IT) | 1983-09-28 | — | — | EP | claimed |
| EP-0016255-A2 | Isoxazole derivative, preparation thereof and pharmaceutical compositions containing the same | ZAMBON S.p.A. (IT) | 1980-10-01 | — | — | EP | claimed |
| EP-0853619-B1 | DISUBSTITUTED PIPERIDINE DERIVATIVES | PHARMACIA & UPJOHN SPA (IT) | 2000-11-02 | — | — | EP | disclosed |
| US-5968955-A | NEUROPROTECTIVE ACTIVITY AND CNS DISEASE | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-10-19 | — | — | US | disclosed |
| EP-0853619-A1 | DISUBSTITUTED PIPERIDINE DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 1998-07-22 | — | — | EP | disclosed |
| WO-1997013769-A1 | DISUBSTITUTED PIPERIDINE DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-04-17 | — | — | WO | disclosed |
| US-4520200-A | CHEMICAL INTERMEDIATES FOR BRONCHODILATOR AGENT | ZAMBON S.P.A. (IT) | 1985-05-28 | — | — | US | disclosed |
| EP-0016255-B1 | ISOXAZOLE DERIVATIVE, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | ZAMBON S.p.A. (IT) | 1983-09-28 | — | — | EP | disclosed |
| US-4276299-A | BRONCHODILATOR AGENTS | ZAMBON S.P.A. (IT) | 1981-06-30 | — | — | US | disclosed |
| EP-0016255-A2 | Isoxazole derivative, preparation thereof and pharmaceutical compositions containing the same | ZAMBON S.p.A. (IT) | 1980-10-01 | — | — | EP | disclosed |