Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | FBP1 | P09467 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8129593 | 1.00 | MAPT (0.54) | MAPTNPC1RAB9AAPPTDP1 | |
| SCHEMBL9566556 | 0.90 | MAPT (0.58) | MAPTNPC1RAB9AAPPTDP1 | |
| SCHEMBL6983254 | 0.89 | MAPT (0.61) | MAPTNPC1RAB9ATDP1LMNA | |
| SCHEMBL24320972 | 0.83 | RAB9A (0.59) | MAPTNPC1RAB9ALMNACYP19A1 | |
| SCHEMBL6984517 | 0.80 | CYP19A1 (0.48) | MAPTNPC1RAB9ATDP1LMNA | |
| SCHEMBL11375992 | 0.79 | APP (0.69) | MAPTNPC1RAB9AAPPLMNA | |
| SCHEMBL11375977 | 0.79 | APP (0.69) | MAPTNPC1RAB9AAPPLMNA | |
| SCHEMBL29769219 | 0.77 | XDH (0.58) | MAPTNPC1RAB9AAPPTDP1 | |
| SCHEMBL458177 | 0.77 | APP (0.78) | MAPTNPC1RAB9AAPPFBP1 | |
| SCHEMBL458178 | 0.77 | APP (0.78) | MAPTNPC1RAB9AAPPFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1290264-A | Triazine angiogenesis inhibitors | ABBOTT LAB (US) | 2001-04-04 | — | — | CN | claimed |
| EP-1037886-A1 | TRIAZINE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2000-09-27 | — | — | EP | claimed |
| WO-1999031088-A1 | TRIAZINE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 1999-06-24 | — | — | WO | claimed |