Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC10A2 | Q12908 | 7/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8492206 | 0.83 | TLR9 (0.39) | MAPK1SYKTLR9TLR7L3MBTL1 | |
| SCHEMBL9563393 | 0.79 | SLC10A2 (0.49) | SLC10A2MAPK1TLR9TLR7L3MBTL1 | |
| SCHEMBL8137994 | 0.64 | SLC10A2 (0.41) | SLC10A2MAPK1TLR9TLR7ALDH1A1 | |
| SCHEMBL7832556 | 0.64 | SLC10A2 (0.39) | SLC10A2TLR9TLR7L3MBTL1ALDH1A1 | |
| SCHEMBL7829714 | 0.64 | SLC10A2 (0.52) | SLC10A2ALDH1A1MAPTKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL8132935 | 0.63 | SLC10A2 (0.51) | SLC10A2ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL9181338 | 0.63 | SLC10A2 (0.47) | SLC10A2MAPK1ALDH1A1MAPTKDM4E | |
| SCHEMBL7819346 | 0.63 | QPCT (0.47) | TLR9TLR7ALDH1A1MAPTKDM4E | |
| SCHEMBL28050431 | 0.61 | LRRK2 (0.51) | ALDH1A1MAPTKDM4EMEN1HPGD | |
| SCHEMBL7825968 | 0.61 | WHR1 (0.46) | L3MBTL1ALDH1A1MAPTKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0634169-B1 | Quinoline or quinazoline derivatives and their use in the manufacture of a medicament for the treatment of osteoporosis | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-01-05 | — | — | EP | disclosed |
| US-5852039-A | Pharmaceutical composition containing quinoline or quinazoline derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-12-22 | — | — | US | disclosed |
| US-5719157-A | OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-17 | — | — | US | disclosed |
| EP-0634169-A1 | Pharmaceutical composition containing quinoline or quinazoline derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-01-18 | — | — | EP | disclosed |
| EP-0567107-A1 | Quinoline and quinazoline derivatives for treating arthritis | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-27 | — | — | EP | disclosed |