Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 9/20 | 0.55 |
| ▸ | RAB9A | P51151 | 8/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | NPC1 | O15118 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | HTT | P42858 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 4/20 | 0.44 |
| ▸ | MMP9 | P14780 | 4/20 | 0.44 |
| ▸ | MMP8 | P22894 | 4/20 | 0.44 |
| ▸ | MMP13 | P45452 | 3/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8132089 | 0.90 | NPBWR1 (0.65) | NPBWR1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL4670013 | 0.89 | NPBWR1 (0.56) | NPBWR1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL7659219 | 0.82 | MMP13 (0.57) | NPBWR1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL9033307 | 0.79 | ALDH1A1 (0.61) | NPBWR1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL3193088 | 0.79 | NPBWR1 (0.80) | NPBWR1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL2361694 | 0.79 | NPBWR1 (0.47) | NPBWR1RAB9AMAPTNPC1HTT | |
| SCHEMBL5758635 | 0.76 | NPBWR1 (0.71) | NPBWR1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL20982681 | 0.76 | NPC1 (0.73) | NPBWR1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL8130390 | 0.75 | ALDH1A1 (0.54) | NPBWR1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL7659225 | 0.74 | MMP13 (0.72) | NPBWR1RAB9AMAPTNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054870-A1 | HETEROCYCLIC TOPOISOMERASE POISONS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041241-A1 | HETEROCYCLIC TOPOISOMERASE POISONS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 1999-08-19 | — | — | WO | disclosed |