Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | MMP2 | P08253 | 3/20 | 0.51 |
| ▸ | MMP9 | P14780 | 3/20 | 0.51 |
| ▸ | MMP8 | P22894 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | GUSB | P08236 | 2/20 | 0.45 |
| ▸ | MMP13 | P45452 | 3/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8132086 | 0.89 | NPBWR1 (0.55) | NPBWR1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL7659219 | 0.83 | MMP13 (0.57) | NPBWR1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL15413801 | 0.82 | NPBWR1 (0.56) | NPBWR1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL28475608 | 0.81 | RAB9A (0.68) | NPBWR1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL22649095 | 0.80 | NPC1 (0.67) | NPBWR1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL2361694 | 0.80 | NPBWR1 (0.47) | NPBWR1RAB9ANPC1MAPTMMP2 | |
| SCHEMBL8132089 | 0.79 | NPBWR1 (0.65) | NPBWR1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL1663325 | 0.78 | CRHBP (0.63) | MAPTMEN1KMT2AL3MBTL1CYP1A2 | |
| SCHEMBL2308775 | 0.77 | NPBWR1 (0.79) | NPBWR1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL20982681 | 0.76 | NPC1 (0.73) | NPBWR1RAB9ANPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1044199-B1 | HETEROCYCLIC TOPOISOMERASE POISONS | UNIV RUTGERS (US) | 2008-07-23 | — | — | EP | disclosed |
| US-20080004280-A1 | Heterocyclic topoisomerase poisons | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2008-01-03 | — | — | US | disclosed |
| US-6995154-B2 | Heterocyclic topoisomerase poisons | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2006-02-07 | — | — | US | disclosed |
| US-20040082637-A1 | Heterocyclic topoisomerase poisons | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2004-04-29 | — | — | US | disclosed |
| US-6667302-B2 | Benzimidazole derivatives as anticancer agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2003-12-23 | — | — | US | disclosed |
| US-20020151575-A1 | Heterocyclic topoisomerase poisons | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2002-10-17 | — | — | US | disclosed |
| US-6399642-B2 | TRIS BENZIMIDAZOLES; FUNGICIDES, ANTICARCINOGENIC AGENTS, ENZYME INHIBITOR | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2002-06-04 | — | — | US | disclosed |
| US-20010009919-A1 | Heterocyclic topoisomerase poisons | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2001-07-26 | — | — | US | disclosed |
| US-6221892-B1 | Heterocyclic topoisomerase poisons | THE STATE OF UNIVERSITY OF NEW JERSEY, RUTGERS | 2001-04-24 | — | — | US | disclosed |
| EP-1054870-A1 | HETEROCYCLIC TOPOISOMERASE POISONS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2000-11-29 | — | — | EP | disclosed |
| EP-1044199-A1 | HETEROCYCLIC TOPOISOMERASE POISONS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2000-10-18 | — | — | EP | disclosed |
| US-6063801-A | Heterocyclic topoisomerase poisons | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2000-05-16 | — | — | US | disclosed |
| WO-1999041241-A1 | HETEROCYCLIC TOPOISOMERASE POISONS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 1999-08-19 | — | — | WO | disclosed |
| WO-1999033824-A1 | HETEROCYCLIC TOPOISOMERASE POISONS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 1999-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004280-A1 | Heterocyclic topoisomerase poisons | TOP1, TOP2A, TOP2B | NPBWR1 4304/4885RAB9A 4650/4885NPC1 3881/4885 |
| US-20040082637-A1 | Heterocyclic topoisomerase poisons | TOP1, TOP2A, TOP2B | NPBWR1 4593/4885RAB9A 4540/4885NPC1 3761/4885 |
| US-20020151575-A1 | Heterocyclic topoisomerase poisons | TOP1, TOP2A, TOP2B | NPBWR1 4756/4885RAB9A 2937/4885NPC1 2228/4885 |
| US-20010009919-A1 | Heterocyclic topoisomerase poisons | TOP1, TOP2A, TOP2B | NPBWR1 4194/4885RAB9A 2315/4885NPC1 2875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.