Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8127298 | 0.92 | L3MBTL1 (0.40) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL8131878 | 0.88 | CLK1 (0.41) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL8117069 | 0.87 | NR1D1 (0.43) | RAB9AKDM4EMAPTMEN1KMT2A | |
| SCHEMBL8131518 | 0.82 | PTPN1 (0.36) | NPC1RAB9AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL8132743 | 0.82 | RAB9A (0.37) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL8132246 | 0.81 | CNR2 (0.43) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL8118630 | 0.80 | ATM (0.46) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL8117486 | 0.75 | MTNR1A (0.38) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL8125097 | 0.75 | MTNR1A (0.62) | KDM4EALDH1A1 | |
| SCHEMBL8124872 | 0.74 | MTNR1A (0.51) | KDM4EALDH1A1CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147110-A | MELATONINERGIC AGENTS; SLEEP, EATING, CENTRAL NERVOUS SYSTEM, AND CARDIOVASCULAR DISORDERS | ADIR ET COMPAGNIE (FR) | 2000-11-14 | — | — | US | disclosed |
| EP-0926145-A1 | Napthalene compounds, method for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-06-30 | — | — | EP | disclosed |