Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CLK3 | P49761 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8127319 | 0.87 | CLK2 (0.45) | TMPRSS2KDM4ECLK2CLK3DYRK1A | |
| SCHEMBL8127514 | 0.84 | KMT2A (0.42) | KDM4EKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL8135503 | 0.83 | HRH3 (0.39) | TMPRSS2HRH3KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL8132714 | 0.81 | ALDH1A1 (0.42) | KDM4EKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL8128276 | 0.77 | MAOA (0.40) | KMT2ASMN1; SMN2 | |
| SCHEMBL22003804 | 0.70 | ACLY (0.49) | HRH3KDM4EALDH1A1NAMPT | |
| SCHEMBL20173801 | 0.69 | KCNA1 (0.47) | TMPRSS2KMT2AMEN1NAMPT | |
| SCHEMBL3440779 | 0.69 | CLK2 (0.42) | TMPRSS2KDM4ECLK2CLK3DYRK1A | |
| SCHEMBL3879495 | 0.68 | ACACB (0.54) | HRH3KDM4EKMT2ASMN1; SMN2GABRA1 | |
| SCHEMBL4752371 | 0.65 | CLK2 (0.42) | TMPRSS2CLK2CLK3DYRK1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008135525-A2 | SUBSTITUTED AZETIDINES, MANUFACTURING AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-11-13 | — | — | WO | disclosed |