Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8145351 | 0.81 | OGA (0.59) | MEN1HTTKMT2AKDM4EGAA | |
| SCHEMBL8142612 | 0.80 | KDM4E (0.53) | MTNR1ACARM1PRMT6KDM4EGAA | |
| SCHEMBL1307498 | 0.79 | NOS2 (0.54) | NOS2DRD2DRD4DRD3CARM1 | |
| SCHEMBL5315582 | 0.79 | NOS2 (0.64) | NOS2DRD2DRD4DRD3MEN1 | |
| SCHEMBL12440506 | 0.78 | NOS2 (0.62) | NOS2DRD2DRD4DRD3CCNA2 | |
| SCHEMBL11777245 | 0.77 | SIGMAR1 (0.56) | NOS2DRD2DRD4DRD3GAA | |
| Hydrochloric Acid SCHEMBL27710837 | 0.77 | NOS2 (0.60) | NOS2DRD2DRD4DRD3CCNA2 | |
| Hydrochloric Acid SCHEMBL11773957 | 0.76 | SIGMAR1 (0.55) | NOS2DRD2DRD4DRD3GAA | |
| SCHEMBL8146680 | 0.76 | THRB (0.55) | MTNR1A | |
| SCHEMBL13656295 | 0.76 | NOS2 (0.56) | NOS2DRD2DRD4DRD3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119741-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2008-10-09 | — | — | WO | disclosed |