Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | DGKA | P23743 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 15/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8121575 | 0.78 | SSTR5 (0.49) | SSTR5LMNATP53CYP2D6MAPT | |
| SCHEMBL9741257 | 0.75 | SSTR5 (0.63) | SSTR5LMNATP53CYP2D6MAPT | |
| SCHEMBL9740810 | 0.75 | HTR1A (0.48) | SSTR5LMNATP53CYP2D6MAPT | |
| SCHEMBL9592694 | 0.75 | HTR1A (0.42) | SSTR5LMNATP53CYP2D6MAPT | |
| Water SCHEMBL9564898 | 0.75 | ALDH1A1 (0.42) | LMNATP53CYP2D6MAPTCYP2C19 | |
| Water SCHEMBL9564895 | 0.75 | ALDH1A1 (0.42) | LMNATP53CYP2D6MAPTCYP2C19 | |
| SCHEMBL9629645 | 0.74 | HTR1A (0.40) | SSTR5LMNATP53CYP2D6MAPT | |
| SCHEMBL8132057 | 0.74 | KDM4E (0.52) | SSTR5LMNAMAPTALDH1A1TSHR | |
| SCHEMBL7147314 | 0.74 | CYP2D6 (0.54) | LMNATP53CYP2D6MAPTCYP2C19 | |
| SCHEMBL7699102 | 0.73 | DRD2 (0.54) | LMNATP53CYP2D6MAPTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539420-B1 | SUBSTITUTED THIAZOLYL AND SUBSTITUTED PYRIDINYL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2000-01-05 | — | — | EP | disclosed |
| US-5360807-A | Substituted thiazolyl and substituted pyridinyl derivatives | JANSSEN PHARMACEUTICA N.V. (BF) | 1994-11-01 | — | — | US | disclosed |
| EP-0539420-A1 | NOVEL SUBSTITUTED THIAZOLYL AND SUBSTITUTED PYRIDINYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-05-05 | — | — | EP | disclosed |
| WO-1992001697-A1 | NOVEL SUBSTITUTED THIAZOLYL AND SUBSTITUTED PYRIDINYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-02-06 | — | — | WO | disclosed |