Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5272522 | 0.78 | BIRC5 (0.46) | NOTUMPKMALDH1A1L3MBTL1HTT | |
| SCHEMBL8140296 | 0.77 | NOTUM (0.47) | NOTUMPKMALDH1A1GAAMAPT | |
| SCHEMBL12270200 | 0.77 | KDM4E (0.32) | ALDH1A1L3MBTL1MAPT | |
| SCHEMBL18885212 | 0.73 | RECQL (0.46) | NOTUMALDH1A1SMN1; SMN2HTTGAA | |
| SCHEMBL28064969 | 0.71 | PTGS2 (0.47) | NOTUMALDH1A1 | |
| SCHEMBL7031169 | 0.71 | MYC (0.59) | NOTUMPKMALDH1A1L3MBTL1HTT | |
| SCHEMBL8137135 | 0.71 | KEAP1 (0.49) | NOTUMALDH1A1L3MBTL1GAAMAPT | |
| SCHEMBL10900906 | 0.70 | ALDH1A1 (0.51) | NOTUMALDH1A1SMN1; SMN2 | |
| SCHEMBL27951163 | 0.70 | CYP3A4 (0.46) | NOTUMALDH1A1L3MBTL1SMN1; SMN2HTT | |
| SCHEMBL1127502 | 0.70 | ATM (0.48) | NOTUMPKMALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040091-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 1999-08-12 | — | — | WO | disclosed |