Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8137135 | 0.78 | KEAP1 (0.49) | NOTUMMGLLGAAMAPTKMT2A | |
| SCHEMBL5272522 | 0.78 | BIRC5 (0.46) | NOTUMKDM4EGAAMAPTKMT2A | |
| SCHEMBL8139682 | 0.77 | NOTUM (0.44) | NOTUMGAAMAPTALDH1A1PKM | |
| SCHEMBL2542214 | 0.77 | MGLL (0.44) | NOTUMMGLLFGFR1IDO1KMT2A | |
| SCHEMBL12270200 | 0.77 | KDM4E (0.32) | KDM4EMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL8139141 | 0.76 | NOTUM (0.51) | NOTUMMGLLFGFR1ALDH1A1PKM | |
| SCHEMBL11176499 | 0.75 | POLB (0.63) | KDM4EGAAMAPTKMT2AALDH1A1 | |
| SCHEMBL1127502 | 0.74 | ATM (0.48) | NOTUMFGFR1KDM4EGAAMAPT | |
| SCHEMBL2222230 | 0.74 | MGLL (0.50) | NOTUMMGLLFGFR1IDO1KMT2A | |
| SCHEMBL8139424 | 0.74 | KDM4E (0.39) | NOTUMMGLLFGFR1IDO1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040091-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 1999-08-12 | — | — | WO | disclosed |