Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776785 | 0.82 | PNMT (0.43) | PNMTALDH1A1ADRA2AADRA2BADRA2C | |
| SCHEMBL2777530 | 0.75 | ALDH1A1 (0.43) | MAPK1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2776754 | 0.74 | PNMT (0.42) | CYP1A2CYP2D6SLC6A4DRD3OPRK1 | |
| SCHEMBL4017459 | 0.71 | PNMT (0.42) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL29806146 | 0.70 | PNMT (0.42) | MAPK1PNMTMAPTALDH1A1ADRA2A | |
| SCHEMBL2778779 | 0.69 | PNMT (0.46) | MAPK1CYP1A2CYP2D6SLC6A4DRD3 | |
| SCHEMBL4429953 | 0.69 | PNMT (0.52) | PNMTMAPTALDH1A1SMN1; SMN2ADRA2A | |
| SCHEMBL2776959 | 0.69 | ALDH1A1 (0.42) | MAPK1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL15016457 | 0.67 | CYP19A1 (0.48) | ALDH1A1KMT2A | |
| SCHEMBL7456470 | 0.67 | PNMT (0.56) | CYP1A2CYP2D6SLC6A4DRD3OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000006146-A9 | SUBSTITUTED ANILIDE COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2000-08-03 | — | — | WO | disclosed |