Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 16/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329029 | 0.77 | FNTA (0.44) | AR | |
| SCHEMBL4231231 | 0.77 | ALDH1A1 (0.57) | ARALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL1121367 | 0.76 | CA3 (0.38) | ALDH1A1HPGDALOX15HSD17B10TDP1 | |
| SCHEMBL15774676 | 0.74 | KIF11 (0.48) | ALDH1A1 | |
| SCHEMBL481292 | 0.72 | KIF11 (0.38) | — | |
| SCHEMBL481057 | 0.72 | ALDH1A1 (0.39) | ARALDH1A1PGR | |
| SCHEMBL5270913 | 0.71 | ESR1 (0.48) | ARALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL4694917 | 0.70 | KIF11 (0.32) | — | |
| SCHEMBL481070 | 0.70 | FAAH (0.31) | AR | |
| SCHEMBL840466 | 0.69 | ESR1 (0.39) | ALDH1A1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6077853-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 2000-06-20 | — | — | US | disclosed |
| EP-0951285-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-10-27 | — | — | EP | disclosed |
| US-5939439-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-08-17 | — | — | US | disclosed |
| WO-1998029119-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1998-07-09 | — | — | WO | disclosed |