Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7909791 | 0.70 | KMT2A (0.42) | ALDH1A1LMNANPC1KMT2ARAB9A | |
| SCHEMBL5784672 | 0.70 | PDE4A (0.40) | LMNANPC1KMT2ARAB9A | |
| SCHEMBL2378171 | 0.66 | LMNA (0.60) | ALDH1A1LMNANPC1KMT2ARAB9A | |
| Bicarbonate SCHEMBL7360481 | 0.66 | NPC1 (0.47) | ALDH1A1LMNANPC1KMT2ARAB9A | |
| SCHEMBL7846691 | 0.64 | NPC1 (0.46) | ALDH1A1LMNANPC1KMT2ARAB9A | |
| SCHEMBL5786283 | 0.63 | NPC1 (0.44) | ALDH1A1LMNANPC1KMT2ARAB9A | |
| SCHEMBL10996648 | 0.63 | LMNA (0.71) | ALDH1A1LMNANPC1KMT2ARAB9A | |
| SCHEMBL23304994 | 0.62 | SIGMAR1 (0.39) | LMNANPC1KMT2ARAB9A | |
| SCHEMBL9928158 | 0.61 | HPGD (0.51) | LMNANPC1KMT2ARAB9A | |
| SCHEMBL11104349 | 0.61 | ALDH1A1 (0.39) | ALDH1A1NPC1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043263-A | (2,3-dihydrobenzofuranyl)-thiazoles as phosphodiesterase inhibitors | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-03-28 | — | — | US | disclosed |
| US-6011037-A | Thiazole derivatives with phosphodiesterase-inhibiting action | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-01-04 | — | — | US | disclosed |