Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.49 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.49 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.47 |
| ▸ | PRCP | P42785 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8152790 | 0.78 | MEN1 (0.53) | DRD2 | |
| SCHEMBL8146862 | 0.78 | DRD2 (0.62) | HRH3DRD2DRD4 | |
| SCHEMBL12841897 | 0.76 | DRD2 (0.70) | HRH3DRD2 | |
| Hydrochloric Acid SCHEMBL9811414 | 0.76 | SIGMAR1 (0.56) | HRH3SLC18A3PRCP | |
| SCHEMBL13436309 | 0.76 | MCHR1 (0.58) | MCHR1HRH3SLC18A3DRD2ADRA1A | |
| SCHEMBL10194714 | 0.73 | QDPR (0.58) | — | |
| SCHEMBL4703335 | 0.73 | HRH3 (0.52) | HRH3CARM1PRMT6SLC18A3DRD2 | |
| SCHEMBL1307142 | 0.73 | HRH3 (0.52) | HRH3CARM1PRMT6SLC18A3DRD2 | |
| SCHEMBL13135462 | 0.73 | CARM1 (0.58) | CARM1PRMT6 | |
| SCHEMBL8139245 | 0.73 | OPRD1 (0.45) | CARM1PRMT6DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119741-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2008-10-09 | — | — | WO | disclosed |