Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.37 |
| ▸ | HTR3B | O95264 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | STAT1 | P42224 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL93286 | 0.81 | CYP3A4 (0.56) | CYP3A4TSHRTRPA1HTR3EHTR3B | |
| Hydrogen Sulfide SCHEMBL27351182 | 0.79 | CYP3A4 (0.54) | CYP3A4TSHRTRPA1HTR3EHTR3B | |
| Methylene Chloride SCHEMBL28742398 | 0.77 | CYP3A4 (0.54) | CYP3A4TSHRTRPA1HTR3EHTR3B | |
| SCHEMBL3341324 | 0.77 | HTR3E (0.45) | CYP3A4TSHRTRPA1HTR3EHTR3B | |
| SCHEMBL20893292 | 0.77 | ALDH1A1 (0.61) | CYP3A4TSHRTRPA1MAPK1TDP1 | |
| SCHEMBL19876727 | 0.75 | CYP3A4 (0.50) | CYP3A4TSHRTRPA1HTR3EHTR3B | |
| Dimethylamine SCHEMBL28015585 | 0.75 | CYP3A4 (0.56) | CYP3A4TSHRTRPA1HTR3EHTR3B | |
| SCHEMBL7585383 | 0.75 | CYP3A4 (0.50) | CYP3A4TSHRTRPA1HTR3EHTR3B | |
| Tromethamine SCHEMBL5026344 | 0.74 | ALDH1A1 (0.41) | CYP3A4TSHRMAPK1TDP1MAPT | |
| SCHEMBL10304668 | 0.74 | CYP3A4 (0.80) | CYP3A4TSHRTRPA1MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117222684-B | Flexible foam comprising flame-retardant polyurethane, method for the production thereof and use thereof | 科莱恩国际有限公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-117222684-A | Flexible foam comprising flame-retardant polyurethane, method for the production thereof and use thereof | 科莱恩国际有限公司 | 2023-12-12 | — | — | CN | disclosed |
| EP-3645594-A1 | TWO-COMPONENT POLYURETHANE COMPOSITION WITH ADJUSTABLE POT LIFE | Sika Technology AG (CH) | 2020-05-06 | — | — | EP | disclosed |
| WO-2000000530-A1 | PRIMER FOR IMPROVING THE BONDING OF ADHESIVES TO NONPOROUS SUBSTRATES | ADCO PRODUCTS, INC. (US) | 2000-01-06 | — | — | WO | disclosed |
| EP-0789736-B1 | ONE-COAT ADHESIVE FOR BONDING CASTABLE URETHANES TO METAL | LORD CORP (US) | 1999-05-06 | — | — | EP | disclosed |
| US-3981828-A | ISOCYANATE TRIMERIZATION CATALYSTS | BASF WYANDOTTE CORPORATION (US) | 1976-09-21 | — | — | US | disclosed |