Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.41 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10526387 | 0.87 | CA2 (0.50) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Tromethamine SCHEMBL7603877 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Tromethamine SCHEMBL8148708 | 0.74 | CYP3A4 (0.44) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Tromethamine SCHEMBL3124288 | 0.72 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| SCHEMBL4266532 | 0.70 | CA2 (0.50) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| SCHEMBL28535163 | 0.69 | GLRA3 (0.47) | ALDH1A1MAPK1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL22815461 | 0.67 | CYP3A4 (0.59) | ALDH1A1TSHRMAPK1CYP1A2CYP3A4 | |
| SCHEMBL1031030 | 0.67 | CA2 (0.56) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| SCHEMBL16829602 | 0.67 | CYP3A4 (0.42) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| SCHEMBL9863186 | 0.66 | CYP3A4 (0.49) | ALDH1A1MAPK1CYP3A4HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3658616-A1 | HALOGEN-FREE SULPHONIC ACID ESTER AND/OR SULPHINIC ACID ESTER AS FLAME RETARDANT, FLAME RETARDANT SYNERGISTS AND RADICAL GENERATORS IN PLASTICS | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) | 2020-06-03 | — | — | EP | claimed |
| US-7341814-B2 | Electrophotographic photoconductor, preparation method thereof, electrophotographic apparatus and process cartridge | RICOH COMPANY, LTD. (JP) | 2008-03-11 | — | — | US | disclosed |
| US-20050181291-A1 | Electrophotographic photoconductor, preparation method thereof, electrophotographic apparatus and process cartridge | RICOH COMPANY, LTD. (JP) | 2005-08-18 | — | — | US | disclosed |
| EP-1211565-A1 | Electrophotographic photoconductor, method of manufacturing same and image forming method, image forming apparatus and process cartridge using same | Ricoh Company, Ltd. (JP) | 2002-06-05 | — | — | EP | disclosed |