Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13010934 | 1.00 | USP2 (0.46) | USP2SMN1; SMN2MAPTALDH1A1CYP3A4 | |
| SCHEMBL12571476 | 0.88 | USP2 (0.48) | USP2SMN1; SMN2MAPTALDH1A1CYP3A4 | |
| SCHEMBL13026177 | 0.86 | SMN1; SMN2 (0.46) | USP2SMN1; SMN2MAPTALDH1A1CYP3A4 | |
| SCHEMBL14706548 | 0.86 | KMT2A (0.43) | USP2SMN1; SMN2MAPTALDH1A1CYP3A4 | |
| SCHEMBL13067403 | 0.86 | SMN1; SMN2 (0.46) | USP2SMN1; SMN2MAPTALDH1A1CYP3A4 | |
| SCHEMBL8402549 | 0.85 | MAPT (0.44) | USP2SMN1; SMN2MAPTALDH1A1CYP3A4 | |
| SCHEMBL13925023 | 0.82 | SMN1; SMN2 (0.55) | USP2SMN1; SMN2MAPTALDH1A1CYP3A4 | |
| SCHEMBL8091831 | 0.82 | SMN1; SMN2 (0.55) | USP2SMN1; SMN2MAPTALDH1A1CYP3A4 | |
| SCHEMBL3777018 | 0.81 | GNPAT (0.49) | USP2SMN1; SMN2MAPTALDH1A1CYP3A4 | |
| SCHEMBL10255206 | 0.81 | PLA2G2C (0.41) | USP2SMN1; SMN2MAPTALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100323953-A1 | MACROCYCLIC HEPATITIS C PROTEASE INHIBITORS | PHENOMIX CORPORATION (US) | 2010-12-23 | — | — | US | disclosed |
| US-20100323953-A1 | MACROCYCLIC HEPATITIS C PROTEASE INHIBITORS | PHENOMIX CORPORATION (US) | 2010-12-23 | — | — | US | disclosed |
| US-7504378-B2 | Macrocyclic peptides active against the hepatitis C virus | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-03-17 | — | — | US | disclosed |
| US-7504378-B2 | Macrocyclic peptides active against the hepatitis C virus | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-03-17 | — | — | US | disclosed |
| WO-2008086161-A1 | MACROCYCLIC HEPATITIS C PROTEASE INHIBITORS | PHENOMIX CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| US-20070249637-A1 | Inhibitors Of Hepatitis C Virus Protease, And Compositions And Treatments Using The Same | COLLINS MICHAEL R | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100323953-A1 | MACROCYCLIC HEPATITIS C PROTEASE INHIBITORS | CTSC, HAVCR2, TMPRSS15 | USP2 807/4885SMN1; SMN2 4531/4885MAPT 4213/4885 |
| US-20070249637-A1 | Inhibitors Of Hepatitis C Virus Protease, And Compositions And Treatments Using The Same | SERPINB1, CTSC, CTSV | USP2 1401/4885SMN1; SMN2 4566/4885MAPT 3214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.