Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11248494 | 0.78 | LMNA (0.43) | MAPTALDH1A1KDM4EHTTHSD17B10 | |
| SCHEMBL10196841 | 0.77 | GAA (0.40) | MAPTALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL9362665 | 0.77 | HRH3 (0.36) | MAPTALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL21384024 | 0.76 | MARS1 (0.43) | MAPTALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL14872174 | 0.76 | KDM4E (0.41) | ALDH1A1KDM4EHTTHSD17B10CYP1A2 | |
| SCHEMBL12877231 | 0.75 | TSHR (0.37) | MAPTALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL17723466 | 0.75 | PTGS2 (0.36) | MAPTALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL6133704 | 0.75 | ALDH1A1 (0.42) | MAPTALDH1A1KDM4EHTTHSD17B10 | |
| SCHEMBL10194702 | 0.74 | KDM4E (0.52) | MAPTALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL24246974 | 0.73 | HRH3 (0.37) | MAPTALDH1A1KDM4EHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11247990-B1 | Bicyclic fused pyridine compounds as inhibitors of TAM kinases | ARRAY BIOPHARMA INC (US) | 2022-02-15 | — | — | US | disclosed |
| WO-2019113190-A1 | BICYCLIC FUSED PYRIDINE COMPOUNDS AS INHIBITORS OF TAM KINASES | ARRAY BIOPHARMA INC. (US) | 2019-06-13 | — | — | WO | disclosed |
| US-20100234352-A1 | FACTOR XA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. | 2010-09-16 | — | — | US | disclosed |
| US-20070185092-A1 | FACTOR Xa INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-08-09 | — | — | US | disclosed |
| US-6071938-A | FOR TREATMENT OF SMOOTH MUSCLE DISORDERS | PFIZER INC. (US) | 2000-06-06 | — | — | US | disclosed |
| US-5912244-A | MUSCLE DISORDERS, BREATHING DISORDERS AND URINARY INCONTINENCE | PFIZER INC. (US) | 1999-06-15 | — | — | US | disclosed |
| EP-0712398-B1 | BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER LTD (GB) | 1997-05-07 | — | — | EP | disclosed |
| CN-1128536-A | Benzopyrans and pharmaceutical compositions containing them | PFIZER LTD (GB) | 1996-08-07 | — | — | CN | disclosed |
| EP-0712398-A1 | BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER LTD (GB) | 1996-05-22 | — | — | EP | disclosed |
| WO-1995004730-A1 | BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER LIMITED (GB) | 1995-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185092-A1 | FACTOR Xa INHIBITORS | TFPI, F12, F11 | MAPT 4564/4885ALDH1A1 1402/4885KDM4E 2399/4885 |
| US-20100234352-A1 | FACTOR XA INHIBITORS | TFPI, F12, F11 | MAPT 4564/4885ALDH1A1 1402/4885KDM4E 2399/4885 |
| US-11247990-B1 | Bicyclic fused pyridine compounds as inhibitors of TAM kinases | MAP3K1, MAP3K3, MAP3K2 | MAPT 1098/4885ALDH1A1 3807/4885KDM4E 1075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.