Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5629773 | 0.75 | ALDH1A1 (0.45) | LMNAALDH1A1MAPK1GAAHSD17B10 | |
| SCHEMBL25650490 | 0.72 | ADH5 (0.43) | CYP3A4IDO1ENPP2MKNK1MKNK2 | |
| SCHEMBL18708315 | 0.68 | LMNA (0.43) | LMNAMAPTMAPK1CYP3A4IDO1 | |
| SCHEMBL2649029 | 0.68 | LMNA (0.43) | LMNAMAPTALDH1A1MAPK1HSD17B10 | |
| SCHEMBL543684 | 0.67 | LMNA (0.49) | LMNAMAPTALDH1A1MAPK1HSD17B10 | |
| SCHEMBL8148319 | 0.66 | CYP11B1 (0.49) | MAPTCYP3A4TSHRCYP2A6 | |
| SCHEMBL31201062 | 0.65 | ALDH1A1 (0.42) | LMNAMAPTALDH1A1MAPK1GAA | |
| SCHEMBL2628931 | 0.65 | CYP3A4 (0.39) | LMNAMAPTALDH1A1MAPK1HSD17B10 | |
| SCHEMBL25650489 | 0.65 | OGA (0.44) | LMNAMAPTALDH1A1MAPK1CYP3A4 | |
| SCHEMBL28061806 | 0.64 | CYP3A4 (0.50) | LMNAMAPTALDH1A1MAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054876-A1 | 1,3,4-THIADIAZOLES DERIVATIVES AS KYN-OH INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999028309-A1 | 1,3,4-THIADIAZOLES DERIVATIVES AS KYN-OH INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-10 | — | — | WO | disclosed |