Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 9/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8114644 | 0.93 | ALDH1A1 (0.39) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8134591 | 0.78 | ALDH1A1 (0.37) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8114668 | 0.78 | GABRP (0.41) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8580696 | 0.76 | ALDH1A1 (0.48) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8840949 | 0.73 | ACHE (0.43) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8607232 | 0.72 | GABRP (0.46) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL10365811 | 0.71 | MAPT (0.41) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8124342 | 0.71 | ALDH1A1 (0.39) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8124757 | 0.71 | ALDH1A1 (0.39) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL9738054 | 0.70 | MAPT (0.41) | LMNAALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015450-A1 | NOVEL PYRIDAZINE COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-07-05 | — | — | EP | disclosed |
| WO-1997045428-A1 | NOVEL PYRIDAZINE COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-12-04 | — | — | WO | disclosed |