SCHEMBL8159378

SCHEMBL8159378

CC(=O)c1nccc(Cl)n1

nearest known ligand 0.44

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SORD Q00796 3/20 0.44
KMO O15229 10/20 0.40
ALDH1A1 P00352 3/20 0.37
PDE3B Q13370 1/20 0.35
PDE3A Q14432 1/20 0.35
SMARCA2 P51531 1/20 0.34
SMARCA4 P51532 1/20 0.34
PANK3 Q9H999 1/20 0.33
MAPK1 P28482 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL287227 0.81 KMO (0.58) KMO
SCHEMBL2773643 0.81 KMO (0.41) KMOALDH1A1SMARCA2SMARCA4SMN1; SMN2
SCHEMBL1206986 0.79 MAP4K4 (0.40) KMOALDH1A1SMN1; SMN2
SCHEMBL18824676 0.79 ALDH1A1 (0.40) KMOALDH1A1MAPK1SMN1; SMN2
SCHEMBL282078 0.79 L3MBTL1 (0.38) KMOSMARCA2SMARCA4SMN1; SMN2
SCHEMBL23795448 0.79 ATR (0.42) KMOALDH1A1
SCHEMBL1256533 0.77 ALDH1A1 (0.47) SORDKMOALDH1A1PDE3BPDE3A
SCHEMBL882969 0.77 SORD (0.45) SORDKMOALDH1A1SMN1; SMN2
Hydrochloric Acid SCHEMBL8170615 0.75 SORD (0.44) SORDKMOALDH1A1PDE3BPDE3A
SCHEMBL16421042 0.75 SORD (0.44) SORDKMOALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-3112479-B2 2000-11-27 JP claimed
EP-0586393-A1 SUBSTITUTED-2-PHENYL-3-METHOXYPROPENOATES AS FUNGICIDES ZENECA LIMITED (GB) 1994-03-16 EP claimed
WO-1992018487-A1 SUBSTITUTED-2-PHENYL-3-METHOXYPROPENOATES AS FUNGICIDES ZENECA LIMITED (GB) 1992-10-29 WO claimed
US-20110313156-A1 HETEROCYCLYL CARBONIC ACID AMIDES AS ANTIPROLIFERATIVE AGENTS, PDKL INHIBITORS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-12-22 US disclosed
US-5814633-A MULTISTAGE FORMATION OF OXYIMINO ANILIDES AS FUNGICIDES BASF AKTIENGESELLSCHAFT (DE) 1998-09-29 US disclosed
CN-1171783-A Iminooxymethylene anilides, process for their preparation and their use BASF AG (DE) 1998-01-28 CN disclosed
EP-0793655-A1 IMINOOXYMETHYLENE ANILIDES, PROCESS FOR PREPARING THE SAME AND THEIR USE BASF AKTIENGESELLSCHAFT (DE) 1997-09-10 EP disclosed
WO-1996016044-A1 IMINOOXYMETHYLENE ANILIDES, PROCESS FOR PREPARING THE SAME AND THEIR USE BASF AKTIENGESELLSCHAFT (DE) 1996-05-30 WO disclosed
EP-0586393-A1 SUBSTITUTED-2-PHENYL-3-METHOXYPROPENOATES AS FUNGICIDES ZENECA LIMITED (GB) 1994-03-16 EP disclosed
WO-1992018487-A1 SUBSTITUTED-2-PHENYL-3-METHOXYPROPENOATES AS FUNGICIDES ZENECA LIMITED (GB) 1992-10-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110313156-A1 HETEROCYCLYL CARBONIC ACID AMIDES AS ANTIPROLIFERATIVE AGENTS, PDKL INHIBITORS PDK2, PDK4, CCNH SORD 1806/4885KMO 3468/4885ALDH1A1 816/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.