Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hypoxanthine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | THPO | P40225 | 1/20 | 0.63 |
| ▸ | MTOR | P42345 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | HBB | P68871 | 1/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | PNP | P00491 | 1/20 | 0.44 |
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | DPYD | Q12882 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mercaptopurine Anhydrous SCHEMBL18317327 | 0.84 | SMN1; SMN2 (0.51) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Hypoxanthine SCHEMBL22323646 | 0.80 | DPYD (0.63) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Hypoxanthine SCHEMBL3348064 | 0.80 | ATAD2 (0.63) | ALDH1A1PNPGDAACHEGRIA1 | |
| Fluorouracil SCHEMBL249289 | 0.80 | MAPT (1.00) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Fluorouracil SCHEMBL3646 | 0.80 | — | — | |
| Fluorouracil SCHEMBL10017187 | 0.80 | — | — | |
| Thioguanine SCHEMBL6928472 | 0.78 | PNP (0.54) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Fluorouracil SCHEMBL15284932 | 0.78 | MAPT (0.95) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Fluorouracil SCHEMBL21880166 | 0.78 | MAPT (0.95) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Fluorouracil SCHEMBL21527805 | 0.78 | MAPT (0.95) | ALDH1A1LMNAMAPTCYP19A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000061749-A1 | CELLULAR PROTEIN P60 THAT INTERACTS WITH HERPESVIRUS REGULATORY PROTEINS | ARCH DEVELOPMENT CORPORATION (US) | 2000-10-19 | — | — | WO | disclosed |