Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPYD | Q12882 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | PNP | P00491 | 1/20 | 0.44 |
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hypoxanthine SCHEMBL3348064 | 0.80 | ATAD2 (0.63) | ALDH1A1PNPGDAACHEGRIA1 | |
| Hypoxanthine SCHEMBL8161237 | 0.80 | ALDH1A1 (0.63) | DPYDALDH1A1PNPGDAACHE | |
| SCHEMBL289873 | 0.80 | DPYD (1.00) | DPYDALDH1A1GAAATAD2LMNA | |
| SCHEMBL7884 | 0.80 | — | — | |
| Hypoxanthine SCHEMBL25381 | 0.78 | ALDH1A1 (1.00) | ALDH1A1PNPGDAACHEGRIA1 | |
| Hypoxanthine SCHEMBL7037918 | 0.78 | ALDH1A1 (1.00) | ALDH1A1PNPGDAACHEGRIA1 | |
| Hypoxanthine SCHEMBL30096461 | 0.78 | ALDH1A1 (1.00) | ALDH1A1PNPGDAACHEGRIA1 | |
| Hypoxanthine SCHEMBL122843 | 0.75 | ALDH1A1 (0.95) | ALDH1A1PNPGDAACHEGRIA1 | |
| Hypoxanthine SCHEMBL2639254 | 0.75 | ALDH1A1 (0.95) | ALDH1A1PNPGDAACHEGRIA1 | |
| Hypoxanthine SCHEMBL560392 | 0.75 | ALDH1A1 (0.95) | ALDH1A1PNPGDAACHEGRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3920916-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | Skyhawk Therapeutics, Inc. (US) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020163382-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. (US) | 2020-08-13 | — | — | WO | disclosed |