Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRB | P28702 | 4/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 3/20 | 0.37 |
| ▸ | RXRG | P48443 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3452332 | 0.88 | RXRB (0.41) | RXRBRXRARXRGMAPTCYP1A2 | |
| SCHEMBL231238 | 0.86 | GRIN2B (0.38) | RXRBGRIN2B | |
| SCHEMBL3453086 | 0.86 | HPGD (0.40) | RXRBRXRARXRGMAPTCYP1A2 | |
| SCHEMBL12379609 | 0.85 | GRIN2B (0.38) | GRIN2B | |
| SCHEMBL12588032 | 0.85 | GRIN2B (0.38) | GRIN2B | |
| SCHEMBL9720050 | 0.81 | TSHR (0.46) | RXRBRXRARXRGMAPTCYP1A2 | |
| SCHEMBL23472586 | 0.81 | MLNR (0.50) | CYP1A2CYP2C9HPGDCYP2C19NPC1 | |
| SCHEMBL81351 | 0.81 | RXRB (0.42) | RXRBRXRARXRGNPC1RAB9A | |
| SCHEMBL6348778 | 0.81 | TPSAB1 (0.43) | RXRBTPSAB1RXRARXRGCYP1A2 | |
| SCHEMBL9110285 | 0.81 | RXRB (0.42) | RXRBTPSAB1RXRARXRGMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168944-B1 | AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2016-05-11 | — | — | EP | disclosed |
| EP-2168944-B1 | AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2016-05-11 | — | — | EP | disclosed |
| CN-101730677-B | Amine compound and pharmaceutical use thereof | MITSUBISHI TANABE PHARMA CORP | 2014-07-16 | — | — | CN | disclosed |
| US-8129361-B2 | Amine compound and pharmaceutical use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129361-B2 | Amine compound and pharmaceutical use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129361-B2 | Amine compound and pharmaceutical use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-03-06 | — | — | US | disclosed |
| US-7858824-B2 | Aralkyltetrahydropyridines, their preparation and pharmaceutical compositions containing them | SANOFI-AVENTIS (FR) | 2010-12-28 | — | — | US | disclosed |
| US-20100179216-A1 | AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-07-15 | — | — | US | disclosed |
| US-20100179216-A1 | AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-07-15 | — | — | US | disclosed |
| US-20100179216-A1 | AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-07-15 | — | — | US | disclosed |
| EP-2168944-A1 | AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-03-31 | — | — | EP | disclosed |
| US-20080097117-A1 | Aralkyltetrahydropyridines, Their Preparation and Pharmaceutical Compositions Containing Them | SANOFI-AVENTIS (FR) | 2008-04-24 | — | — | US | disclosed |
| US-7326723-B2 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2008-02-05 | — | — | US | disclosed |
| EP-1438291-B1 | ARALKYL-TETRAHYDRO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI AVENTIS (FR) | 2005-09-07 | — | — | EP | disclosed |
| US-20050014795-A1 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2005-01-20 | — | — | US | disclosed |
| EP-1438291-A1 | ARALKYL-TETRAHYDRO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Sanofi-Aventis (FR) | 2004-07-21 | — | — | EP | disclosed |
| WO-2003033466-A1 | ARALKYL-TETRAHYDRO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2003-04-24 | — | — | WO | disclosed |
| US-4078066-A | HYPOTENSIVE AGENTS, SURFACTANTS, BACTERICIDES AND WATER SOFTENERS | E. R. SQUIBB & SONS, INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-4033971-A | HYPOTENSIVES, SURFACTANTS, BACTERICIDES, WATER SOFTENERS | E. R. SQUIBB & SONS, INC. (US) | 1977-07-05 | — | — | US | disclosed |
| US-3936465-A | SURFACTANT, WATER SOFTENER, BACTERICIDE, HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1976-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014795-A1 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | CYCS, NADK, CYP2F1 | RXRB 1476/4885TPSAB1 2017/4885RXRA 1524/4885 |
| US-20080097117-A1 | Aralkyltetrahydropyridines, Their Preparation and Pharmaceutical Compositions Containing Them | CYP3A43, CYCS, CCNY | RXRB 2350/4885TPSAB1 909/4885RXRA 2262/4885 |
| US-20100179216-A1 | AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF | HLA-B, HLA-A, HLA-C | RXRB 2681/4885TPSAB1 1579/4885RXRA 2753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.