Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3452332 | 0.98 | RXRB (0.41) | HPGDMAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9720050 | 0.86 | TSHR (0.46) | HPGDMAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL81619 | 0.86 | RXRB (0.39) | HPGDMAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3284644 | 0.82 | TSHR (0.42) | HPGDMAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3279449 | 0.80 | RXRB (0.42) | HPGDMAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL231238 | 0.79 | GRIN2B (0.38) | RXRBALOX15 | |
| SCHEMBL9711010 | 0.79 | DRD2 (0.39) | RXRBCETP | |
| SCHEMBL17186185 | 0.78 | TAAR1 (0.47) | MAPTCYP1A2CYP2C19TDP1ADRA2A | |
| SCHEMBL30496730 | 0.78 | TAAR1 (0.47) | MAPTCYP1A2CYP2C19TDP1ADRA2A | |
| SCHEMBL8853672 | 0.78 | ALDH1A1 (0.48) | HPGDMAPTCYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7858824-B2 | Aralkyltetrahydropyridines, their preparation and pharmaceutical compositions containing them | SANOFI-AVENTIS (FR) | 2010-12-28 | — | — | US | disclosed |
| US-20080097117-A1 | Aralkyltetrahydropyridines, Their Preparation and Pharmaceutical Compositions Containing Them | SANOFI-AVENTIS (FR) | 2008-04-24 | — | — | US | disclosed |
| US-7326723-B2 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2008-02-05 | — | — | US | disclosed |
| EP-1438291-B1 | ARALKYL-TETRAHYDRO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI AVENTIS (FR) | 2005-09-07 | — | — | EP | disclosed |
| US-20050014795-A1 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014795-A1 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | CYCS, NADK, CYP2F1 | HPGD 350/4885MAPT 3304/4885CYP1A2 15/4885 |
| US-20080097117-A1 | Aralkyltetrahydropyridines, Their Preparation and Pharmaceutical Compositions Containing Them | CYP3A43, CYCS, CCNY | HPGD 250/4885MAPT 2797/4885CYP1A2 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.