Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.48 |
| ▸ | DRD4 | P21917 | 6/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21250762 | 0.73 | TSHR (0.43) | ACHEKMT2A | |
| SCHEMBL8244044 | 0.73 | DRD2 (0.48) | DRD2DRD4HTR2AADRA2CEGFR | |
| SCHEMBL28170415 | 0.68 | ACHE (0.46) | DRD2ACHEHTR2AHTR2CHTR2B | |
| SCHEMBL8157632 | 0.68 | NOS3 (0.50) | ACHEHTR2AMAPTMAPK1 | |
| SCHEMBL22566378 | 0.65 | ACHE (0.42) | DRD2ACHEHTR2AHTR2CHTR2B | |
| SCHEMBL17987100 | 0.63 | HTR1A (0.62) | DRD2HTR2AADRA2CEGFRLMNA | |
| SCHEMBL17249923 | 0.63 | DNMT1 (0.64) | DRD2DRD4EGFRLMNAMAPT | |
| SCHEMBL4649553 | 0.62 | DNMT1 (0.83) | DRD2DRD4EGFRLMNAMAPT | |
| SCHEMBL6001718 | 0.62 | DRD2 (0.52) | DRD2DRD4HTR2ADRD3HTR1A | |
| SCHEMBL1200699 | 0.62 | ACHE (0.56) | DRD2ACHEHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021397-A4 | BENZANTHRONE COMPOUNDS AND ANTIVIRAL USES THEREOF | TRIMERIS INC (US) | 2000-10-04 | — | — | EP | disclosed |
| EP-1021397-A1 | BENZANTHRONE COMPOUNDS AND ANTIVIRAL USES THEREOF | TRIMERIS INC. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1998039287-A1 | BENZANTHRONE COMPOUNDS AND ANTIVIRAL USES THEREOF | TRIMERIS, INC. (US) | 1998-09-11 | — | — | WO | disclosed |