SCHEMBL8166370

SCHEMBL8166370

Cc1cc(Oc2ccc(C(C)(C)c3ccc(Oc4ccc(N)c(C)c4)cc3)cc2)ccc1N

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.47
MAPT P10636 7/20 0.47
HPGD P15428 4/20 0.47
RAB9A P51151 3/20 0.47
NPC1 O15118 2/20 0.47
MAPK1 P28482 1/20 0.47
NR4A1 P22736 1/20 0.45
TSHR P16473 3/20 0.41
TDP1 Q9NUW8 2/20 0.41
CYP3A4 P08684 1/20 0.41
KMT2A Q03164 4/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
MEN1 O00255 3/20 0.41
ESR1 P03372 3/20 0.40
AR P10275 1/20 0.40
ESR2 Q92731 1/20 0.40
TEAD4 Q15561 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
GFER P55789 2/20 0.38
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24683907 0.95 NR4A1 (0.55) ALDH1A1MAPTHPGDRAB9ANPC1
SCHEMBL26768373 0.89 ALDH1A1 (0.58) ALDH1A1MAPTHPGDRAB9ANPC1
SCHEMBL23530428 0.89 ALDH1A1 (0.47) ALDH1A1MAPTHPGDRAB9ANPC1
SCHEMBL7865351 0.87 ALDH1A1 (0.47) ALDH1A1MAPTHPGDRAB9ANPC1
SCHEMBL8762387 0.87 NR4A1 (0.58) ALDH1A1MAPTHPGDRAB9ANPC1
SCHEMBL8174397 0.86 ALDH1A1 (0.47) ALDH1A1MAPTHPGDRAB9ANPC1
SCHEMBL7866785 0.85 NR4A1 (0.65) ALDH1A1MAPTHPGDRAB9ANPC1
SCHEMBL486670 0.84 NR4A1 (0.61) ALDH1A1MAPTHPGDRAB9ANPC1
SCHEMBL9541829 0.84 L3MBTL1 (0.50) ALDH1A1MAPTHPGDRAB9ANPC1
SCHEMBL9177309 0.83 MAPT (0.49) ALDH1A1MAPTHPGDRAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0032745-B1 ETHER IMIDES AND PROCESS FOR PRODUCING THE SAME Hitachi, Ltd. (JP) 1987-01-07 EP claimed
US-4460783-A AMIDATION, CYCLIZATION, DEHYDRATION HITACHI, LTD. (JP) 1984-07-17 US claimed
EP-0032745-A2 Ether imides and process for producing the same Hitachi, Ltd. (JP) 1981-07-29 EP claimed
US-6051722-A PRECURSOR FOR POLYIMIDE COPOLYMER; USABLE IN OPTICAL LONG-DISTANCE COMMUNICATION, SIGNAL PROCESSING, PHOTOELECTRIC HYBRID CIRCUITS AND OPTICAL COMPUTERS HITACHI CHEMICAL COMPANY, LTD. (JP) 2000-04-18 US disclosed
US-5419932-A Polyamide alignment film CANON KABUSHIKI KAISHA (JP) 1995-05-30 US disclosed
EP-0499159-A2 Liquid crystal device and dislay apparatus CANON KABUSHIKI KAISHA (JP) 1992-08-19 EP disclosed
EP-0446719-A1 Amino phenoxy compounds and process for their preparation Bromine Compounds Ltd. (IL) 1991-09-18 EP disclosed