Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 14/20 | 0.35 |
| ▸ | CHRM2 known ✓ | P08172 | 10/20 | 0.35 |
| ▸ | CHRM3 known ✓ | P20309 | 10/20 | 0.35 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 10/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 10/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 10/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2135868 | 0.81 | PNMT (0.32) | PNMT | |
| Hydrochloric Acid SCHEMBL8167195 | 0.80 | CYP1A2 (0.30) | CYP2D6CYP1A2CYP2C9CYP2C19 | |
| Fluoride Ion SCHEMBL3470296 | 0.79 | PNMT (0.32) | PNMT | |
| Hydrochloric Acid SCHEMBL3894866 | 0.75 | PNMT (0.33) | DRD3PNMT | |
| Hydrochloric Acid SCHEMBL8170585 | 0.71 | PGR (0.35) | DRD3PNMT | |
| SCHEMBL8161787 | 0.70 | CHRM1 (0.39) | TSHRALDH1A1ATMNPSR1HRH1 | |
| SCHEMBL8163480 | 0.67 | CHRM1 (0.38) | TSHRALDH1A1ATMNPSR1HRH1 | |
| Hydrochloric Acid SCHEMBL2143359 | 0.67 | PGR (0.30) | — | |
| Hydrochloric Acid SCHEMBL8159955 | 0.66 | PGR (0.33) | PNMT | |
| Hydrochloric Acid SCHEMBL978987 | 0.66 | NPC1 (0.36) | CYP1A2ADRA2ASLC6A2SLC6A4PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2000313713-A | PRODUCTION OF POLYOLEFIN HAVING WIDE MOLECULAR WEIGHT DISTRIBUTION | ELANAC GMBH | 2000-11-14 | — | — | JP | disclosed |