Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5688812 | 0.85 | NPC1 (0.34) | NPC1RAB9APNMT | |
| Hydrochloric Acid SCHEMBL617844 | 0.80 | NPC1 (0.37) | NPC1RAB9APNMTPGRCYP1A2 | |
| Hydrochloric Acid SCHEMBL5087314 | 0.78 | PNMT (0.38) | NPC1RAB9APNMTPGR | |
| Fluoride Ion SCHEMBL3469916 | 0.78 | NPC1 (0.37) | NPC1RAB9APNMTPGRCYP1A2 | |
| SCHEMBL6522771 | 0.78 | NPC1 (0.37) | NPC1RAB9APNMTPGRCYP1A2 | |
| SCHEMBL5718001 | 0.77 | PNMT (0.39) | NPC1RAB9APNMTPGRHTR2B | |
| SCHEMBL8108526 | 0.77 | NPC1 (0.36) | NPC1RAB9APNMTPGRCYP1A2 | |
| Hydrochloric Acid SCHEMBL978984 | 0.76 | NPC1 (0.36) | NPC1RAB9APNMTPGRCYP1A2 | |
| Hydrochloric Acid SCHEMBL822337 | 0.73 | NPC1 (0.36) | NPC1RAB9APNMTPGRHTR2B | |
| Hydrochloric Acid SCHEMBL5355300 | 0.70 | PGR (0.41) | NPC1RAB9APNMTPGRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036034-A | A syndiospecific polymerization catalyst having non-bilateral symmetry to obtain an amorphous poly-alpha-olefin | FINA TECHNOLOGY, INC. (US) | 1991-07-30 | — | — | US | claimed |
| EP-0423101-A2 | Catalyst for producing hemiisotactic polypropylene | FINA TECHNOLOGY, INC. (US) | 1991-04-17 | — | — | EP | claimed |
| US-8802782-B2 | Modified polyolefins with an exceptional profile of properties, process for preparation thereof and use thereof | EVONIK DEGUSSA GMBH (DE) | 2014-08-12 | — | — | US | disclosed |
| US-20110003095-A1 | MODIFIED POLYOLEFINS WITH AN EXCEPTIONAL PROFILE OF PROPERTIES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF | EVONIK DEGUSSA GMBH (DE) | 2011-01-06 | — | — | US | disclosed |
| EP-0423101-B2 | Catalyst for producing hemiisotactic polypropylene | FINA TECHNOLOGY (US) | 2006-05-03 | — | — | EP | disclosed |
| US-6369175-B1 | ACTIVATING METALLOCENE CATALYST WITH METHYLALUMINOXANE; CATALYTIC ADDITION HOMOPOLYMERIZATION; BLENDING WITH SYNDIOTACTIC POLYPROPYLENE; PLASTICIZERS | FINA TECHNOLOGY, INC. | 2002-04-09 | — | — | US | disclosed |
| US-6369175-B1 | ACTIVATING METALLOCENE CATALYST WITH METHYLALUMINOXANE; CATALYTIC ADDITION HOMOPOLYMERIZATION; BLENDING WITH SYNDIOTACTIC POLYPROPYLENE; PLASTICIZERS | FINA TECHNOLOGY, INC. | 2002-04-09 | — | — | US | disclosed |
| EP-0742227-B1 | Hemiisotactic polypropylene as a plasticizer for syndiotactic or isotactic polypropylene | FINA TECHNOLOGY (US) | 2001-03-14 | — | — | EP | disclosed |
| CN-1058022-C | A catalyst for producing hemiisotactic polypropylene | FINA TECHNOLOGY (US) | 2000-11-01 | — | — | CN | disclosed |
| EP-0423101-B1 | Catalyst for producing hemiisotactic polypropylene | FINA TECHNOLOGY (US) | 2000-01-26 | — | — | EP | disclosed |
| EP-0742227-A2 | Catalyst for producing hemiisotactic polypropylene and composition containing said hemiostatic polypropylane | FINA TECHNOLOGY, INC. (US) | 1996-11-13 | — | — | EP | disclosed |
| EP-0742227-A2 | Catalyst for producing hemiisotactic polypropylene and composition containing said hemiostatic polypropylane | FINA TECHNOLOGY, INC. (US) | 1996-11-13 | — | — | EP | disclosed |
| CN-1028532-C | Catalyst for producing semi-isotactic polypropylene | FINA TECHNOLOGY (US) | 1995-05-24 | — | — | CN | disclosed |
| CN-1100733-A | A catalyst for producing hemiisotactic polypropylene | FINA TECHNOLOGY (US) | 1995-03-29 | — | — | CN | disclosed |
| US-5036034-A | A syndiospecific polymerization catalyst having non-bilateral symmetry to obtain an amorphous poly-alpha-olefin | FINA TECHNOLOGY, INC. (US) | 1991-07-30 | — | — | US | disclosed |
| US-5036034-A | A syndiospecific polymerization catalyst having non-bilateral symmetry to obtain an amorphous poly-alpha-olefin | FINA TECHNOLOGY, INC. (US) | 1991-07-30 | — | — | US | disclosed |
| EP-0423101-A2 | Catalyst for producing hemiisotactic polypropylene | FINA TECHNOLOGY, INC. (US) | 1991-04-17 | — | — | EP | disclosed |
| EP-0423101-A2 | Catalyst for producing hemiisotactic polypropylene | FINA TECHNOLOGY, INC. (US) | 1991-04-17 | — | — | EP | disclosed |