Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 11/20 | 0.58 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8703967 | 0.94 | CCR5 (0.48) | CCR5PTGER1RXRAXDH | |
| SCHEMBL8701112 | 0.91 | CCR5 (0.46) | CCR5PTGER1RXRAXDH | |
| SCHEMBL1907786 | 0.91 | RXRA (0.53) | CCR5PTGER1RXRA | |
| SCHEMBL8161455 | 0.90 | PTGER1 (0.54) | CCR5PTGER1MRGPRX4RXRA | |
| SCHEMBL8162210 | 0.90 | ALDH1A1 (0.45) | CCR5PTGER1NPSR1RXRAXDH | |
| SCHEMBL8163058 | 0.87 | RXRA (0.53) | PTGER1MRGPRX4RXRA | |
| SCHEMBL8167611 | 0.87 | CCR5 (0.56) | CCR5PTGER1STAT3NPSR1 | |
| SCHEMBL7672615 | 0.84 | HCAR3 (0.51) | RXRA | |
| SCHEMBL7963005 | 0.84 | HCAR3 (0.44) | CCR5RXRA | |
| SCHEMBL7963047 | 0.84 | HCAR3 (0.44) | CCR5RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773930-B1 | AROMATIC AMINO ETHERS AS PAIN RELIEVING AGENTS | ZENECA LTD (GB) | 2000-10-11 | — | — | EP | claimed |
| US-5843942-A | Aromatic amino ethers as pain relieving agents | ZENECA LIMITED (GB) | 1998-12-01 | — | — | US | disclosed |
| EP-0773930-A1 | AROMATIC AMINO ETHERS AS PAIN RELIEVING AGENTS | ZENECA LIMITED (GB) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996003380-A1 | AROMATIC AMINO ETHERS AS PAIN RELIEVING AGENTS | ZENECA LIMITED (GB) | 1996-02-08 | — | — | WO | disclosed |