Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6378224 | 0.88 | CYP2C19 (0.70) | CYP2C19SMN1; SMN2DPP7SIGMAR1KMT2A | |
| SCHEMBL4133414 | 0.83 | SIGMAR1 (0.67) | DPP7SIGMAR1KMT2A | |
| SCHEMBL22634135 | 0.81 | SIGMAR1 (0.63) | DPP7SIGMAR1KMT2A | |
| SCHEMBL8553564 | 0.80 | DRD4 (0.70) | CYP2C19SIGMAR1GAAKMT2ACYP2D6 | |
| SCHEMBL16291177 | 0.79 | MEN1 (0.68) | SIGMAR1KMT2A | |
| SCHEMBL11560101 | 0.78 | GAA (0.62) | GAAALDH1A1KMT2ACYP2D6 | |
| SCHEMBL14761452 | 0.78 | CYP2D6 (0.71) | SIGMAR1ALDH1A1KMT2ACYP2D6 | |
| SCHEMBL10554681 | 0.78 | DRD4 (0.64) | CYP2C19DPP7SIGMAR1GAAKMT2A | |
| SCHEMBL22470297 | 0.77 | MEN1 (0.62) | GAAKMT2A | |
| SCHEMBL7424698 | 0.77 | ACHE (0.64) | DPP7SIGMAR1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156752-A | Optically active 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC (US) | 2000-12-05 | — | — | US | disclosed |
| EP-0899261-A1 | Optical active 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC. (US) | 1999-03-03 | — | — | EP | disclosed |