SCHEMBL818765

SCHEMBL818765

C=C(C)C(=O)Oc1cccc2[nH]nnc12

nearest known ligand 0.37

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ELANE P08246 1/20 0.37
ATM Q13315 2/20 0.33
MAPT P10636 2/20 0.33
PDE5A O76074 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
PARP1 P09874 1/20 0.32
HPSE Q9Y251 1/20 0.32
KMT2A Q03164 1/20 0.32
SLC22A6 Q4U2R8 1/20 0.32
MAOB P27338 1/20 0.30
ADORA2A P29274 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8844752 0.89 MAPT (0.33) ATMMAPTPDE5ATDP1PARP1
SCHEMBL27561443 0.88 PDE5A (0.39) ELANEATMPDE5ATDP1PARP1
SCHEMBL7707716 0.86 SLC22A6 (0.44) MAPTPDE5ATDP1KMT2ASLC22A6
SCHEMBL27464332 0.85 ATM (0.34) ATMMAPTTDP1PARP1HPSE
SCHEMBL44289 0.83 MAPT (0.33) MAPTPARP1HPSEMAOBADORA2A
SCHEMBL44290 0.81 LMNA (0.35) MAPTTDP1KMT2AMAOBADORA2A
SCHEMBL5585189 0.80 GABRG2 (0.35) ELANEMAPTPDE5AKMT2AMAOB
SCHEMBL14690221 0.80 MAPT (0.32) MAPTPARP1
SCHEMBL2534586 0.80 MEN1 (0.38) MAPTPARP1KMT2A
SCHEMBL8590357 0.79 THRB (0.38) MAPTTDP1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080031918-A1 BARRIERS FOR POLYMERIC COATINGS SURMODICS, INC. 2008-02-07 US claimed
EP-1567203-B1 BARRIERS FOR BIOACTIVE AGENT-CONTAINING POLYMERIC COATINGS SURMODICS INC (US) 2007-09-26 EP claimed
JP-3954616-B2 2007-08-08 JP claimed
US-7097850-B2 Bioactive agent release coating and controlled humidity method SURMODICS, INC. (US) 2006-08-29 US claimed
EP-1551469-B1 BIOACTIVE AGENT RELEASE COATING WITH AROMATIC POLY(METH)ACRYLATES SURMODICS INC (US) 2006-03-08 EP claimed
JP-2006505303-A 2006-02-16 JP claimed
EP-1567203-A2 BARRIERS FOR BIOACTIVE AGENT-CONTAINING POLYMERIC COATINGS SurModics, Inc. (US) 2005-08-31 EP claimed
EP-1551469-A1 BIOACTIVE AGENT RELEASE COATING WITH AROMATIC POLY(METH)ACRYLATES SurModics, Inc. (US) 2005-07-13 EP claimed
EP-1534354-A1 METHOD AND SYSTEM FOR PROVIDING BIOACTIVE AGENT RELEASE COATING SurModics, Inc. (US) 2005-06-01 EP claimed
EP-1517714-A1 BIOACTIVE AGENT RELEASE COATING AND CONTROLLED HUMIDITY METHOD SurModics, Inc. (US) 2005-03-30 EP claimed
WO-2004052420-A2 BARRIERS FOR BIOACTIVE AGENT-CONTAINING POLYMERIC COATINGS SURMODICS, INC. (US) 2004-06-24 WO claimed
US-20040111144-A1 Barriers for polymeric coatings Surmodics Coatings, LLC 2004-06-10 US claimed
WO-2003105920-A1 METHOD AND SYSTEM FOR PROVIDING BIOACTIVE AGENT RELEASE COATING SURMODICS, INC. (US) 2003-12-24 WO claimed
WO-2003105918-A1 BIOACTIVE AGENT RELEASE COATING WITH AROMATIC POLY(METH)ACRYLATES SURMODICS, INC. (US) 2003-12-24 WO claimed
WO-2003105919-A1 BIOACTIVE AGENT RELEASE COATING AND CONTROLLED HUMIDITY METHOD SURMODICS, INC. (US) 2003-12-24 WO claimed
US-20030232122-A1 Bioactive agent release coating and controlled humidity method Surmodics Coatings, LLC 2003-12-18 US claimed
US-20030232087-A1 Bioactive agent release coating with aromatic poly(meth)acrylates Surmodics Coatings, LLC 2003-12-18 US claimed
US-20020188037-A1 Method and system for providing bioactive agent release coating Surmodics Coatings, LLC 2002-12-12 US claimed
JP-5295303-A None JP disclosed
EP-0049860-A1 Process for the preparation of reactive thyroid gland hormones T3 and T4 derivatives that are capable of coupling, and their use Roche Diagnostics GmbH (DE) 1982-04-21 EP disclosed