Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11380734 | 0.76 | BRD4 (0.42) | BRD4TP53CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL6928031 | 0.75 | SMN1; SMN2 (0.31) | BRD4SMN1; SMN2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL1139285 | 0.75 | BRD4 (0.47) | BRD4TP53CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL17014460 | 0.75 | BRD4 (0.47) | BRD4TP53CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL4868550 | 0.75 | BRD4 (0.47) | BRD4TP53CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL12953852 | 0.74 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL17756080 | 0.73 | BRD4 (0.42) | BRD4TP53CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL22144319 | 0.73 | BRD4 (0.42) | BRD4TP53CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL15445855 | 0.73 | BRD4 (0.42) | BRD4TP53CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL15768178 | 0.73 | BRD4 (0.42) | BRD4TP53CHRNB2CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10059681-B2 | Disubstituted maleic anhydrides with altered kinetics of ring closure | Arrowhead Pharmaceuticals, Inc. (US) | 2018-08-28 | — | — | US | disclosed |
| US-9481661-B2 | Disubstituted maleic anhydrides with altered kinetics of ring closure | Arrowhead Madison, Inc. (US) | 2016-11-01 | — | — | US | disclosed |
| US-9481661-B2 | Disubstituted maleic anhydrides with altered kinetics of ring closure | Arrowhead Madison, Inc. (US) | 2016-11-01 | — | — | US | disclosed |
| US-9481661-B2 | Disubstituted maleic anhydrides with altered kinetics of ring closure | Arrowhead Madison, Inc. (US) | 2016-11-01 | — | — | US | disclosed |
| US-20160272605-A1 | Disubstituted Maleic Anhydrides with Altered Kinetics of Ring Closure | SIXTH STREETLENDING PARTNERS, AS THE ADMINISTRATIVE AGENT | 2016-09-22 | — | — | US | disclosed |
| US-20160272605-A1 | Disubstituted Maleic Anhydrides with Altered Kinetics of Ring Closure | SIXTH STREETLENDING PARTNERS, AS THE ADMINISTRATIVE AGENT | 2016-09-22 | — | — | US | disclosed |
| US-20160272605-A1 | Disubstituted Maleic Anhydrides with Altered Kinetics of Ring Closure | SIXTH STREETLENDING PARTNERS, AS THE ADMINISTRATIVE AGENT | 2016-09-22 | — | — | US | disclosed |
| US-20140128584-A1 | Disubstituted Maleic Anhydrides with Altered Kinetics of Ring Closure | Arrowhead Madison Inc. (US) | 2014-05-08 | — | — | US | disclosed |
| US-20140128584-A1 | Disubstituted Maleic Anhydrides with Altered Kinetics of Ring Closure | Arrowhead Madison Inc. (US) | 2014-05-08 | — | — | US | disclosed |
| US-20140128584-A1 | Disubstituted Maleic Anhydrides with Altered Kinetics of Ring Closure | Arrowhead Madison Inc. (US) | 2014-05-08 | — | — | US | disclosed |
| US-8415496-B2 | Biobased polyesters | Amyris, Inc. | 2013-04-09 | — | — | US | disclosed |
| US-8367858-B2 | Terephthalic and trimellitic based acids and carboxylate derivatives thereof | Amyris, Inc. (US) | 2013-02-05 | — | — | US | disclosed |
| US-8367859-B2 | Cyclohexane 1,4 carboxylates | Amyris, Inc. (US) | 2013-02-05 | — | — | US | disclosed |
| WO-2012173784-A1 | DISUBSTITUTED MALEIC ANHYDRIDES WITH ALTERED KINETICS OF RING CLOSURE | Arrowhead Madison Inc. (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012173784-A1 | DISUBSTITUTED MALEIC ANHYDRIDES WITH ALTERED KINETICS OF RING CLOSURE | Arrowhead Madison Inc. (US) | 2012-12-20 | — | — | WO | disclosed |
| US-20110288263-A1 | BIOBASED POLYESTERS | DRATHS CORPORATION (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110288311-A1 | NOVEL TEREPHTHALIC AND TRIMELLITIC BASED ACIDS AND CARBOXYLATE DERIVATIVES THEREOF | DRATHS CORPORATION (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110288310-A1 | CYCLOHEXANE 1,4 CARBOXYLATES | DRATHS CORPORATION (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110282078-A1 | CYCLOHEXENE 1,4 -CARBOXYLATES | DRATHS CORPORATION (US) | 2011-11-17 | — | — | US | disclosed |
| US-20100314243-A1 | PREPARATION OF TRANS,TRANS MUCONIC ACID AND TRANS,TRANS MUCONATES | DRATHS CORPORATION (US) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288310-A1 | CYCLOHEXANE 1,4 CARBOXYLATES | CNR2, CBR1, CCR4 | BRD4 224/4885TP53 2929/4885CHRNB2 3335/4885 |
| US-20140128584-A1 | Disubstituted Maleic Anhydrides with Altered Kinetics of Ring Closure | SRM, CA1, AADAC | BRD4 1092/4885TP53 2986/4885CHRNB2 4275/4885 |
| US-20110282078-A1 | CYCLOHEXENE 1,4 -CARBOXYLATES | CBR1, MCM4, CCR4 | BRD4 176/4885TP53 2492/4885CHRNB2 3225/4885 |
| US-20160272605-A1 | Disubstituted Maleic Anhydrides with Altered Kinetics of Ring Closure | SRM, CA1, AADAC | BRD4 1092/4885TP53 2986/4885CHRNB2 4275/4885 |
| US-20110288311-A1 | NOVEL TEREPHTHALIC AND TRIMELLITIC BASED ACIDS AND CARBOXYLATE DERIVATIVES THEREOF | TRIM4, DDT, PICALM | BRD4 3441/4885TP53 1978/4885CHRNB2 3093/4885 |
| US-20100314243-A1 | PREPARATION OF TRANS,TRANS MUCONIC ACID AND TRANS,TRANS MUCONATES | MUC1, FUT6, ST6GAL1 | BRD4 4776/4885TP53 1643/4885CHRNB2 3762/4885 |
| US-10059681-B2 | Disubstituted maleic anhydrides with altered kinetics of ring closure | SRM, CA1, AADAC | BRD4 1092/4885TP53 2986/4885CHRNB2 4275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.