Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM5C | P41229 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.38 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8191026 | 0.94 | ALDH1A1 (0.43) | ALDH1A1LMNAHSP90AB1CYP19A1CNR2 | |
| SCHEMBL8198730 | 0.82 | HSP90AB1 (0.43) | ALDH1A1LMNAHSP90AB1CYP19A1MEN1 | |
| SCHEMBL8185813 | 0.82 | CNR2 (0.48) | ALDH1A1LMNAHSP90AB1CYP19A1CNR2 | |
| SCHEMBL4733672 | 0.80 | ALDH1A1 (0.44) | ALDH1A1LMNAHSP90AB1CYP19A1CNR2 | |
| SCHEMBL4738911 | 0.80 | CACNA1H (0.40) | CNR2 | |
| SCHEMBL8193111 | 0.77 | LMNA (0.41) | ALDH1A1LMNAHSP90AB1CYP19A1CDC7 | |
| SCHEMBL8192162 | 0.77 | TGM2 (0.40) | ALDH1A1LMNAHSP90AB1KDM4AKDM5C | |
| SCHEMBL8193397 | 0.75 | ALDH1A1 (0.47) | ALDH1A1LMNAHSP90AB1CDC7MEN1 | |
| SCHEMBL4738910 | 0.75 | CACNA1H (0.42) | ALDH1A1CYP19A1CNR2HPGDSMN1; SMN2 | |
| SCHEMBL4737953 | 0.75 | AURKA (0.42) | ALDH1A1LMNACDC7MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |