Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Temazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP known ✓ | O00591 | 2/20 | 0.59 |
| ▸ | GABRD known ✓ | O14764 | 2/20 | 0.59 |
| ▸ | GABRA1 known ✓ | P14867 | 2/20 | 0.59 |
| ▸ | GABRB1 known ✓ | P18505 | 2/20 | 0.59 |
| ▸ | GABRG2 known ✓ | P18507 | 2/20 | 0.59 |
| ▸ | GABRB3 known ✓ | P28472 | 2/20 | 0.59 |
| ▸ | GABRA5 known ✓ | P31644 | 2/20 | 0.59 |
| ▸ | GABRA3 known ✓ | P34903 | 2/20 | 0.59 |
| ▸ | GABRA2 known ✓ | P47869 | 2/20 | 0.59 |
| ▸ | GABRB2 known ✓ | P47870 | 2/20 | 0.59 |
| ▸ | GABRA4 known ✓ | P48169 | 2/20 | 0.59 |
| ▸ | GABRE known ✓ | P78334 | 2/20 | 0.59 |
| ▸ | GABRA6 known ✓ | Q16445 | 2/20 | 0.59 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 2/20 | 0.59 |
| ▸ | GABRG3 known ✓ | Q99928 | 2/20 | 0.59 |
| ▸ | GABRQ known ✓ | Q9UN88 | 2/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Temazepam SCHEMBL29463 | 1.00 | OPRK1 (1.00) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| Temazepam SCHEMBL29398512 | 1.00 | OPRK1 (1.00) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| Temazepam SCHEMBL5503177 | 1.00 | OPRK1 (1.00) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| Temazepam SCHEMBL29464 | 1.00 | OPRK1 (1.00) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| Temazepam SCHEMBL16922195 | 1.00 | OPRK1 (1.00) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| Temazepam SCHEMBL10480110 | 0.99 | OPRK1 (0.98) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| Lormetazepam SCHEMBL1758605 | 0.93 | OPRK1 (0.89) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| Temazepam SCHEMBL23038565 | 0.91 | OPRK1 (0.83) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| Temazepam SCHEMBL8140373 | 0.91 | OPRK1 (0.83) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| Temazepam SCHEMBL7036032 | 0.90 | OPRK1 (0.82) | OPRK1LMNAPDE3APDE4DCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6018 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025226985-A1 | PASSIVATION OF POLYSILICON MATERIAL AND SELECTIVE DEPOSITION OF DIELECTRIC MATERIAL UTILIZING ALKYNES | VERSUM MATERIALS US, LLC (US) | 2025-10-30 | — | — | WO | claimed |
| US-20250331242-A1 | THIN FILM STRUCTURE AND SEMICONDUCTOR DEVICE COMPRISING THE SAME | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2025-10-23 | — | — | US | claimed |
| US-20250085301-A1 | DATE RAPE DRUG DETECTION DEVICE AND METHOD OF USING SAME | EHRLICH ELAN (IL) | 2025-03-13 | — | — | US | claimed |
| WO-2025052373-A1 | DATE RAPE DRUG DETECTION DEVICE AND METHOD OF USING SAME | EHRLICH ELAN (IL) | 2025-03-13 | — | — | WO | claimed |
| CN-119569575-A | Preparation method and deposition method of IVB-group metal organic precursor | 中船(邯郸)派瑞特种气体股份有限公司 | 2025-03-07 | — | — | CN | claimed |
| US-20250076324-A1 | DATE RAPE DRUG DETECTION DEVICE AND METHOD OF USING SAME | EHRLICH ELAN (IL) | 2025-03-06 | — | — | US | claimed |
| US-20250076321-A1 | DATE RAPE DRUG DETECTION DEVICE AND METHOD OF USING SAME | EHRLICH ELAN (IL) | 2025-03-06 | — | — | US | claimed |
| US-20250076322-A1 | DATE RAPE DRUG DETECTION DEVICE AND METHOD OF USING SAME | EHRLICH ELAN (IL) | 2025-03-06 | — | — | US | claimed |
| US-20250076323-A1 | DATE RAPE DRUG DETECTION DEVICE AND METHOD OF USING SAME | EHRLICH ELAN (IL) | 2025-03-06 | — | — | US | claimed |
| CN-119563046-A | In situ generation of H2S or H2Se during growth of two-dimensional films of transition metal disulfides and/or diselenides | 默克专利股份有限公司 | 2025-03-04 | — | — | CN | claimed |
| CN-86103285-A | The method of coating fibre and device thereof | — | 1987-04-22 | — | — | CN | claimed |
| EP-0216148-A2 | Bituminous surfacing for roads and process for making bituminous surfacings in the cold state for roads | Vialit Kaltasphalt Gesellschaft m. b. H. (AT) | 1987-04-01 | — | — | EP | claimed |
| EP-0081194-B1 | BITUMINOUS PAVEMENT REPAIR METHOD | Schölkopf, Walter (DE) | 1986-04-23 | — | — | EP | claimed |
| EP-0072491-B1 | BRAKE FOR ROLLING CONTAINERS | Lermer GmbH (DE) | 1985-11-21 | — | — | EP | claimed |
| EP-0085790-B1 | RAILWAY TRACK RECONDITIONING TRAIN | LES FILS D'AUGUSTE SCHEUCHZER S.A. (CH) | 1985-08-21 | — | — | EP | claimed |
| EP-0028668-B1 | TRAIN FOR STABILISING A RAILWAY TRACK | LES FILS D'AUGUSTE SCHEUCHZER S.A. (CH) | 1984-04-18 | — | — | EP | claimed |
| EP-0092179-A1 | Embedding unit of paving stones for producing soil covers, and process for producing the paving units and soil covers | Heinrich-Ludwig Wahrendorf oHG (DE) | 1983-10-26 | — | — | EP | claimed |
| EP-0081194-A1 | Bituminous pavement repair method | Schölkopf, Walter (DE) | 1983-06-15 | — | — | EP | claimed |
| EP-0072491-A1 | Brake for rolling containers | Lermer GmbH (DE) | 1983-02-23 | — | — | EP | claimed |
| EP-0060044-A1 | Fluidised bed combustion | EMS THERMPLANT LIMITED (GB) | 1982-09-15 | — | — | EP | claimed |