Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3140129 | 0.89 | NPC1 (0.33) | NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL6238419 | 0.84 | JAK2 (0.33) | SMN1; SMN2MAPTALDH1A1KDM4EMAPK1 | |
| SCHEMBL4630510 | 0.83 | KCNA3 (0.32) | — | |
| SCHEMBL28464019 | 0.83 | SMN1; SMN2 (0.32) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL11352154 | 0.82 | KMT2A (0.40) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL29265292 | 0.82 | APP (0.38) | SMN1; SMN2MAPTALDH1A1KDM4EMAPK1 | |
| SCHEMBL7281298 | 0.82 | L3MBTL1 (0.37) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7779040 | 0.82 | L3MBTL1 (0.37) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL8196711 | 0.80 | KCNA3 (0.34) | — | |
| SCHEMBL2449865 | 0.80 | L3MBTL1 (0.38) | SMN1; SMN2MAPTALDH1A1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000001687-A9 | BENZOTHIEPINES HAVING ACTIVITY AS INHIBITORS OF ILEAL BILE ACID TRANSPORT AND TAUROCHOLATE UPTAKE | SEARLE & CO (US) | 2000-07-20 | — | — | WO | disclosed |