Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | ILK | Q13418 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8195495 | 0.91 | TP53 (0.37) | MAPK14MAPTTP53RAB9AKMT2A | |
| SCHEMBL8200074 | 0.90 | LMNA (0.38) | MAPTTP53L3MBTL1POLBGSK3B | |
| SCHEMBL8195725 | 0.90 | RPS6KA3 (0.40) | MAPK14MAPTL3MBTL1RAB9AKMT2A | |
| SCHEMBL8195834 | 0.84 | IKBKE (0.39) | MAPTTP53GSK3BSMN1; SMN2ALDH1A1 | |
| SCHEMBL8196103 | 0.83 | GRK6 (0.38) | MAPTTP53L3MBTL1KMT2ASMN1; SMN2 | |
| SCHEMBL8199147 | 0.82 | KMO (0.36) | MAPTPOLBKMT2AHTTMAPK10 | |
| SCHEMBL8639382 | 0.77 | MAPK14 (0.44) | MAPK14GSK3BPTGS2 | |
| SCHEMBL8187508 | 0.74 | MEN1 (0.33) | CYP1A2KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL6180868 | 0.72 | PTGS2 (0.55) | MAPK14PTGS2 | |
| SCHEMBL8202075 | 0.68 | PTGS2 (0.37) | MAPTKMT2AHTTMEN1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018741-A2 | PYRAZOLE COMPOUNDS AS COX-2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-04-06 | — | — | WO | disclosed |