Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 2/20 | 0.30 |
| ▸ | MMP14 | P50281 | 2/20 | 0.30 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8424487 | 0.82 | MMP2 (0.41) | MMP1MMP13MMP9MMP14MMP2 | |
| SCHEMBL8198199 | 0.81 | ADAM17 (0.34) | MMP1MMP8ADAM17MMP13MMP9 | |
| SCHEMBL7513209 | 0.78 | MMP1 (0.44) | MMP1MMP8ADAM17MMP13MMP9 | |
| SCHEMBL9010568 | 0.77 | MMP1 (0.35) | MMP1MMP8ADAM17MMP13MMP9 | |
| SCHEMBL8422654 | 0.76 | MMP1 (0.34) | MMP1MMP8ADAM17MMP13MMP9 | |
| SCHEMBL9010562 | 0.74 | ADAM17 (0.34) | MMP1MMP8ADAM17MMP13MMP9 | |
| SCHEMBL8189731 | 0.74 | MMP1 (0.32) | MMP1MMP8ADAM17MMP13MMP9 | |
| SCHEMBL8424797 | 0.74 | MMP1 (0.32) | MMP1MMP8ADAM17MMP13MMP9 | |
| SCHEMBL8422672 | 0.74 | GAA (0.39) | MMP1MMP8ADAM17MMP13MMP9 | |
| SCHEMBL9010548 | 0.73 | ADAM17 (0.33) | MMP1MMP8ADAM17MMP13MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0740655-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1996-11-06 | — | — | EP | claimed |
| WO-1995019961-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-07-27 | — | — | WO | claimed |
| US-6017889-A | Metalloproteinase inhibitors | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2000-01-25 | — | — | US | disclosed |
| EP-0740655-B1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 1999-10-20 | — | — | EP | disclosed |
| EP-0740655-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1996-11-06 | — | — | EP | disclosed |
| WO-1995019961-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-07-27 | — | — | WO | disclosed |