Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 2/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8194012 | 0.82 | ADK (0.43) | ADK | |
| SCHEMBL8194100 | 0.77 | ADK (0.43) | ADK | |
| SCHEMBL1110166 | 0.75 | CYP2C19 (0.42) | PIK3CA | |
| SCHEMBL8185210 | 0.69 | ADK (0.33) | ADK | |
| SCHEMBL8193074 | 0.68 | LMNA (0.33) | — | |
| SCHEMBL4573322 | 0.67 | MAPT (0.36) | — | |
| SCHEMBL8192330 | 0.64 | ADK (0.30) | ADK | |
| SCHEMBL8218481 | 0.64 | ALDH1A1 (0.41) | ADKPIK3CAMTOR | |
| SCHEMBL12615095 | 0.63 | HRH4 (0.47) | — | |
| SCHEMBL8193374 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | claimed |
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | disclosed |