Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8200595 | 0.87 | ALDH1A1 (0.45) | HTR2CSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8199345 | 0.86 | CCR2 (0.46) | HTR2C | |
| SCHEMBL8199643 | 0.84 | CCR5 (0.48) | HTR2CDRD3DRD2HTR7 | |
| SCHEMBL8200188 | 0.83 | KDM4E (0.44) | HTR2CSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL8200414 | 0.82 | PRCP (0.44) | HTR2CALDH1A1MEN1KMT2A | |
| SCHEMBL8200402 | 0.81 | HTR2C (0.48) | HTR2CDRD3DRD2HTR7DRD4 | |
| SCHEMBL8198484 | 0.80 | HTR2C (0.42) | HTR2CMEN1KMT2ATSHRDRD3 | |
| SCHEMBL8199832 | 0.79 | PRCP (0.56) | HTR2CALDH1A1KDM4E | |
| SCHEMBL8192538 | 0.79 | PRCP (0.56) | HTR2CALDH1A1KDM4E | |
| SCHEMBL8205410 | 0.79 | DRD2 (0.41) | SMN1; SMN2DRD3DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |