Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGPL1 | O95470 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8199670 | 0.80 | HTR2C (0.43) | — | |
| SCHEMBL8192821 | 0.79 | THRA (0.42) | SGPL1S1PR1THRATHRBSMYD3 | |
| SCHEMBL8200249 | 0.77 | THRA (0.52) | SGPL1S1PR1THRATHRBITGB3 | |
| SCHEMBL8205603 | 0.77 | SMN1; SMN2 (0.48) | MAPK14 | |
| SCHEMBL8192695 | 0.77 | THRA (0.49) | SGPL1S1PR1THRATHRBITGB3 | |
| SCHEMBL8199839 | 0.75 | MLYCD (0.45) | SGPL1S1PR1THRATHRB | |
| SCHEMBL18052663 | 0.70 | THRA (0.53) | SGPL1S1PR1THRATHRBCYP26A1 | |
| SCHEMBL8201692 | 0.70 | MLYCD (0.42) | SGPL1S1PR1THRBITGB3ITGA2B | |
| SCHEMBL15954361 | 0.69 | THRA (0.52) | SGPL1S1PR1THRATHRBCYP26A1 | |
| SCHEMBL15954358 | 0.69 | THRA (0.52) | SGPL1S1PR1THRATHRBCYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |