Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 3/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8192821 | 0.92 | THRA (0.42) | MLYCDNAMPTITGB3ITGA2BMAPK14 | |
| SCHEMBL8198845 | 0.85 | MLYCD (0.40) | MLYCDNAMPTITGB3ITGA2BCYP26A1 | |
| SCHEMBL8200547 | 0.81 | HTR2C (0.48) | NAMPT | |
| SCHEMBL8205603 | 0.78 | SMN1; SMN2 (0.48) | MAPK14MAPTKMT2A | |
| SCHEMBL8203558 | 0.76 | MLYCD (0.48) | MLYCDNAMPTMAPK14S1PR1KMT2A | |
| SCHEMBL8588802 | 0.73 | HTR2C (0.48) | TP53MAPTTHRB | |
| SCHEMBL8199839 | 0.72 | MLYCD (0.45) | MLYCDNAMPTSGPL1S1PR1THRB | |
| SCHEMBL8199972 | 0.72 | HTR2C (0.46) | KMT2A | |
| SCHEMBL8589013 | 0.71 | MLYCD (0.45) | MLYCDNAMPTTP53MAPTKMT2A | |
| SCHEMBL8589012 | 0.71 | MLYCD (0.45) | MLYCDNAMPTTP53MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |