Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 1/20 | 0.45 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 5/20 | 0.43 |
| ▸ | TACR1 | P25103 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205119 | 0.86 | CCR2 (0.45) | P2RX1TMPRSS4CCR2TACR1LMNA | |
| SCHEMBL8200050 | 0.83 | CCR2 (0.55) | CCR2TACR1 | |
| SCHEMBL8199839 | 0.74 | MLYCD (0.45) | P2RX1TMPRSS4CCR2HPGDMLYCD | |
| SCHEMBL8198484 | 0.70 | HTR2C (0.42) | CCR2 | |
| SCHEMBL8199345 | 0.70 | CCR2 (0.46) | P2RX1TMPRSS4CCR2TACR1P2RX7 | |
| SCHEMBL6866336 | 0.70 | CHRNB2 (0.68) | P2RX1TMPRSS4TACR1HTT | |
| SCHEMBL16088678 | 0.69 | P2RX1 (0.57) | P2RX1TMPRSS4TACR1LMNAHPGD | |
| SCHEMBL16127840 | 0.68 | KMT2A (0.65) | P2RX1TMPRSS4TACR1MLYCDMTOR | |
| SCHEMBL6862802 | 0.68 | TACR1 (0.61) | P2RX1TMPRSS4TACR1LMNAHPGD | |
| SCHEMBL16128007 | 0.68 | P2RX1 (0.55) | P2RX1TMPRSS4TACR1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |