Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 8/20 | 0.38 |
| ▸ | MMP3 | P08254 | 7/20 | 0.38 |
| ▸ | MMP2 | P08253 | 6/20 | 0.38 |
| ▸ | MMP9 | P14780 | 5/20 | 0.38 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 3/20 | 0.35 |
| ▸ | MMP14 | P50281 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SDCBP | O00560 | 1/20 | 0.31 |
| ▸ | SDC2 | P34741 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7377721 | 0.79 | MMP1 (0.43) | MMP1MMP3MMP2MMP9MMP8 | |
| SCHEMBL9010635 | 0.77 | RAB9A (0.42) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL8189876 | 0.74 | MMP1 (0.43) | MMP1MMP3MMP2MMP9MMP8 | |
| SCHEMBL8198456 | 0.72 | MMP1 (0.64) | MMP1MMP3MMP2MMP9MMP8 | |
| SCHEMBL27258950 | 0.68 | MMP2 (0.44) | MMP1MMP3MMP2MMP9MMP8 | |
| SCHEMBL8198041 | 0.65 | MMP2 (0.39) | MMP1MMP3MMP2MMP9MMP8 | |
| SCHEMBL6948374 | 0.63 | PTPN1 (0.45) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL7405620 | 0.62 | RAB9A (0.42) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL7405615 | 0.62 | RAB9A (0.42) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL9287472 | 0.62 | MMP9 (0.41) | MMP1MMP3MMP2MMP9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017889-A | Metalloproteinase inhibitors | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2000-01-25 | — | — | US | disclosed |
| EP-0740655-B1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 1999-10-20 | — | — | EP | disclosed |
| EP-0740655-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1996-11-06 | — | — | EP | disclosed |
| WO-1995019961-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-07-27 | — | — | WO | disclosed |