Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 4/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8211593 | 0.89 | ALOX5 (0.52) | ALOX5KCNH2PARP14PARP10MMP13 | |
| SCHEMBL8209387 | 0.89 | S1PR5 (0.42) | S1PR5FFAR1KMT2A | |
| SCHEMBL8209442 | 0.84 | KDM1A (0.43) | ALOX5KCNH2PARP10MMP13HTT | |
| SCHEMBL8213085 | 0.77 | MMP13 (0.46) | ALOX5KCNH2PARP14PARP10MMP13 | |
| SCHEMBL8210831 | 0.76 | BTK (0.35) | KCNH2MMP13HTT | |
| SCHEMBL8209566 | 0.73 | POLB (0.45) | PARP10MMP13MEN1POLBKMT2A | |
| SCHEMBL8209192 | 0.70 | MMP13 (0.49) | KCNH2PARP10MMP13S1PR5 | |
| SCHEMBL8208991 | 0.70 | NPC1 (0.41) | FFAR1MEN1KMT2A | |
| SCHEMBL8778208 | 0.68 | ALOX5 (0.79) | ALOX5KCNH2PARP14PARP10 | |
| SCHEMBL8778183 | 0.68 | ALOX5 (0.79) | ALOX5KCNH2PARP14PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114361-A | INHIBITORS OF MATRIX METALLOPROTEINASES AND REPROLYSIN; ADMINISTERING TO TREAT CONDITIONS WHICH CAN BE TREATED BY THE INHIBITION OF THESE ENZYMES | PFIZER INC. (US) | 2000-09-05 | — | — | US | claimed |